An integrated microfluidic cell for detection, manipulation, and sorting of single micron-sized magnetic beads

Z. Jiang; J. Llandro; T. Mitrelias; J. A.C. Bland

doi:10.1063/1.2176238

An integrated microfluidic cell for detection, manipulation, and sorting of single micron-sized magnetic beads

Z. Jiang, J. Llandro, T. Mitrelias, J. A.C. Bland

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

A lab-on-a-chip integrated microfluidic cell has been developed for magnetic biosensing, which is comprised of anisotropic magnetoresistance (AMR) sensors optimized for the detection of single magnetic beads and electrodes to manipulate and sort the beads, integrated into a microfluidic channel. The device is designed to read out the real-time signal from 9 μm diameter magnetic beads moving over AMR sensors patterned into 18×4.5 μm rectangles and 10 μm diameter rings and arranged in Wheatstone bridges. The beads are moved over the sensors along a 75×75 μm wide channel patterned in SU8. Beads of different magnetic moments can be sorted through a magnetostatic sorting gate into different branches of the microfluidic channel using a magnetic field gradient applied by lithographically defined 120 nm thick Cu striplines carrying 0.2 A current.

Original language	English
Article number	08S105
Journal	Journal of Applied Physics
Volume	99
Issue number	8
DOIs	https://doi.org/10.1063/1.2176238
Publication status	Published - 2006
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy(all)

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10.1063/1.2176238

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title = "An integrated microfluidic cell for detection, manipulation, and sorting of single micron-sized magnetic beads",

abstract = "A lab-on-a-chip integrated microfluidic cell has been developed for magnetic biosensing, which is comprised of anisotropic magnetoresistance (AMR) sensors optimized for the detection of single magnetic beads and electrodes to manipulate and sort the beads, integrated into a microfluidic channel. The device is designed to read out the real-time signal from 9 μm diameter magnetic beads moving over AMR sensors patterned into 18×4.5 μm rectangles and 10 μm diameter rings and arranged in Wheatstone bridges. The beads are moved over the sensors along a 75×75 μm wide channel patterned in SU8. Beads of different magnetic moments can be sorted through a magnetostatic sorting gate into different branches of the microfluidic channel using a magnetic field gradient applied by lithographically defined 120 nm thick Cu striplines carrying 0.2 A current.",

author = "Z. Jiang and J. Llandro and T. Mitrelias and Bland, {J. A.C.}",

note = "Funding Information: The authors gratefully acknowledge St. Edmunds College (Z.J.) and EPSRC (J.L.), respectively, for funding support of this paper and travel to the 50th MMM meeting.",

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T1 - An integrated microfluidic cell for detection, manipulation, and sorting of single micron-sized magnetic beads

AU - Jiang, Z.

AU - Llandro, J.

AU - Mitrelias, T.

AU - Bland, J. A.C.

N1 - Funding Information: The authors gratefully acknowledge St. Edmunds College (Z.J.) and EPSRC (J.L.), respectively, for funding support of this paper and travel to the 50th MMM meeting.

PY - 2006

Y1 - 2006

N2 - A lab-on-a-chip integrated microfluidic cell has been developed for magnetic biosensing, which is comprised of anisotropic magnetoresistance (AMR) sensors optimized for the detection of single magnetic beads and electrodes to manipulate and sort the beads, integrated into a microfluidic channel. The device is designed to read out the real-time signal from 9 μm diameter magnetic beads moving over AMR sensors patterned into 18×4.5 μm rectangles and 10 μm diameter rings and arranged in Wheatstone bridges. The beads are moved over the sensors along a 75×75 μm wide channel patterned in SU8. Beads of different magnetic moments can be sorted through a magnetostatic sorting gate into different branches of the microfluidic channel using a magnetic field gradient applied by lithographically defined 120 nm thick Cu striplines carrying 0.2 A current.

AB - A lab-on-a-chip integrated microfluidic cell has been developed for magnetic biosensing, which is comprised of anisotropic magnetoresistance (AMR) sensors optimized for the detection of single magnetic beads and electrodes to manipulate and sort the beads, integrated into a microfluidic channel. The device is designed to read out the real-time signal from 9 μm diameter magnetic beads moving over AMR sensors patterned into 18×4.5 μm rectangles and 10 μm diameter rings and arranged in Wheatstone bridges. The beads are moved over the sensors along a 75×75 μm wide channel patterned in SU8. Beads of different magnetic moments can be sorted through a magnetostatic sorting gate into different branches of the microfluidic channel using a magnetic field gradient applied by lithographically defined 120 nm thick Cu striplines carrying 0.2 A current.

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An integrated microfluidic cell for detection, manipulation, and sorting of single micron-sized magnetic beads

Abstract

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