TY - JOUR
T1 - An inverted J-shaped association of serum uric acid with muscle strength among Japanese adult men
T2 - A cross-sectional study
AU - Huang, Cong
AU - Niu, Kaijun
AU - Kobayashi, Yoritoshi
AU - Guan, Lei
AU - Momma, Haruki
AU - Cui, Yufei
AU - Chujo, Masahiro
AU - Otomo, Atsushi
AU - Guo, Hui
AU - Tadaura, Hiroko
AU - Nagatomi, Ryoichi
N1 - Funding Information:
We thank Professor R. Molino-Lova (Cardiac Rehabilitation Unit, Don Gnocchi Foundation, Via Imprunetana 124, 50023, Pozzolatico, Florence, Italy) and Qiang Li, PhD (Department of Public Health, Xi’an Jiaotong University College of Medicine, 710061, Xi’an, Shaanxi, China) for their fruitful discussions and comments. We are also extremely grateful to all of the subjects whose participation made this study possible. This study was supported by a Grant-in-Aid under the Knowledge Cluster Initiative from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2013
Y1 - 2013
N2 - Background: Uric acid (UA) may protect muscle function from oxidative damage due to reactive oxygen species through its powerful antioxidant capacity. However, several studies have demonstrated that hyperuricemia is closely related to systemic inflammation and has oxidant properties effects, both of which may increase the risk of muscle strength loss. The purpose of this study was to examine the association of serum UA concentration with grip strength and leg extension power in adult men. Methods. This study is a cross-sectional survey in which 630 Japanese male employees aged 30 years and older participated. Five hundred and eighty-six subjects participated in the measurement of grip strength, and 355 subjects participated in the measurement of leg extension power. Blood samples were obtained for serum UA analysis. Results: After adjustment for potential confounders, grip strength differed significantly between participants with and those without hyperuricemia (geometric mean and 95% confidence interval [CI]: 40.3 [39.2-41.3] kg vs. 41.9 [41.3-42.5] kg; P = 0.01). In addition, serum UA levels (quartiles) showed an inverted J-shaped curve with grip strength (mean and 95% CI: Q1, 41.6 [40.6-42.6] kg; Q2, 42.2 [41.2-43.2] kg; Q3, 41.8 [40.8-42.8] kg; Q4, 40.4 [39.3-41.4] kg; P for quadratic trend = 0.05). The results in the leg extension power group were similar to those observed in the grip strength group. Conclusion: This population-based cross-sectional study shows for the first time that hyperuricemia is associated with poor muscle strength. Moreover, the results indicate an inverted J-shaped association between serum UA quartiles and muscle strength.
AB - Background: Uric acid (UA) may protect muscle function from oxidative damage due to reactive oxygen species through its powerful antioxidant capacity. However, several studies have demonstrated that hyperuricemia is closely related to systemic inflammation and has oxidant properties effects, both of which may increase the risk of muscle strength loss. The purpose of this study was to examine the association of serum UA concentration with grip strength and leg extension power in adult men. Methods. This study is a cross-sectional survey in which 630 Japanese male employees aged 30 years and older participated. Five hundred and eighty-six subjects participated in the measurement of grip strength, and 355 subjects participated in the measurement of leg extension power. Blood samples were obtained for serum UA analysis. Results: After adjustment for potential confounders, grip strength differed significantly between participants with and those without hyperuricemia (geometric mean and 95% confidence interval [CI]: 40.3 [39.2-41.3] kg vs. 41.9 [41.3-42.5] kg; P = 0.01). In addition, serum UA levels (quartiles) showed an inverted J-shaped curve with grip strength (mean and 95% CI: Q1, 41.6 [40.6-42.6] kg; Q2, 42.2 [41.2-43.2] kg; Q3, 41.8 [40.8-42.8] kg; Q4, 40.4 [39.3-41.4] kg; P for quadratic trend = 0.05). The results in the leg extension power group were similar to those observed in the grip strength group. Conclusion: This population-based cross-sectional study shows for the first time that hyperuricemia is associated with poor muscle strength. Moreover, the results indicate an inverted J-shaped association between serum UA quartiles and muscle strength.
KW - Antioxidant
KW - Grip strength
KW - Inflammation
KW - Leg extension power
KW - Reactive oxygen species
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U2 - 10.1186/1471-2474-14-258
DO - 10.1186/1471-2474-14-258
M3 - Article
C2 - 24000893
AN - SCOPUS:84883176112
SN - 1471-2474
VL - 14
JO - BMC Musculoskeletal Disorders
JF - BMC Musculoskeletal Disorders
M1 - 258
ER -