TY - JOUR
T1 - An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor
AU - Yoshikawa, Keiichi
AU - Nakagawa, Hiroaki
AU - Mori, Naoki
AU - Watanabe, Hidenori
AU - Touhara, Kazushige
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research (S) from the Ministry of Education, Culture, Sports, Science and Technology Japan (grant 24227003), a Grant-in-Aid for Scientific Research on Priority Areas from the Japan Society for the Promotion of Science (JSPS) (grant 18077001) and a research grant from the Astellas Foundation for Research on Metabolic Disorders to K.T. K.Y. was supported by a Grant-in-Aid for JSPS fellows. We thank T. Ando for Z8-14:OH (Tokyo University of Agriculture and Technology), and T. Kikusui and T. Hattori for advice on behavioral experiments.
PY - 2013/3
Y1 - 2013/3
N2 - We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.
AB - We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.
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U2 - 10.1038/nchembio.1164
DO - 10.1038/nchembio.1164
M3 - Article
C2 - 23314914
AN - SCOPUS:84874049140
SN - 1552-4450
VL - 9
SP - 160
EP - 162
JO - Nature Chemical Biology
JF - Nature Chemical Biology
IS - 3
ER -