TY - JOUR
T1 - Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis
AU - Kaneta, Tomohiro
AU - Okamura, Nobuyuki
AU - Arai, Akira
AU - Takanami, Kentaro
AU - Furukawa, Katsutoshi
AU - Tashiro, Manabu
AU - Furumoto, Shozo
AU - Iwata, Ren
AU - Takahashi, Shoki
AU - Arai, Hiroyuki
AU - Yanai, Kazuhiko
AU - Kudo, Yukitsuka
N1 - Funding Information:
Acknowledgments This work was supported by JSPS KAKENHI Grant Number 24591745.
PY - 2014/3
Y1 - 2014/3
N2 - Purpose: To examine the usefulness of the early phase [11C]BF- 227 positron emission tomography (PET) for (1) conferring additional diagnostic value by providing perfusion-like information and (2) obtaining the appropriate anatomical standardization (AS) using three-dimensional stereotactic surface projection (3D-SSP) method. Methods: This study included 20 mild cognitive impairment (MCI), 19 Alzheimer's disease (AD), and 17 normal cognitive (NC) subjects. Early- and late-phase BF-227 PET images were obtained 0-10 and 40-60 min after the injection, respectively. AS for late-phase BF-227 images were performed by 2 methods: (1) method A, for AS of late-phase BF-227 images using 8F-fluorodeoxyglucose (FDG) images of the same subject and (2) method B, for AS of late-phase BF-227 images using early phase BF-227 images. Results: Method B was successfully used for AS in all cases. The Z score maps of 3D-SSP analyses of FDG PET and early phase BF-227 PET for AD and MCI groups showed a typical AD-like pattern. Regional analyses revealed that the early phase BF-227 PET showed significant differences between AD and NC, and MCI and NC. Conclusion: The early phase BF-227 PET images showed significant abnormal findings for the AD and MCI groups. AS of late-phase BF-227 images using early phase BF-227 images were successful, and enabled appropriate 3D-SSP analyses.
AB - Purpose: To examine the usefulness of the early phase [11C]BF- 227 positron emission tomography (PET) for (1) conferring additional diagnostic value by providing perfusion-like information and (2) obtaining the appropriate anatomical standardization (AS) using three-dimensional stereotactic surface projection (3D-SSP) method. Methods: This study included 20 mild cognitive impairment (MCI), 19 Alzheimer's disease (AD), and 17 normal cognitive (NC) subjects. Early- and late-phase BF-227 PET images were obtained 0-10 and 40-60 min after the injection, respectively. AS for late-phase BF-227 images were performed by 2 methods: (1) method A, for AS of late-phase BF-227 images using 8F-fluorodeoxyglucose (FDG) images of the same subject and (2) method B, for AS of late-phase BF-227 images using early phase BF-227 images. Results: Method B was successfully used for AS in all cases. The Z score maps of 3D-SSP analyses of FDG PET and early phase BF-227 PET for AD and MCI groups showed a typical AD-like pattern. Regional analyses revealed that the early phase BF-227 PET showed significant differences between AD and NC, and MCI and NC. Conclusion: The early phase BF-227 PET images showed significant abnormal findings for the AD and MCI groups. AS of late-phase BF-227 images using early phase BF-227 images were successful, and enabled appropriate 3D-SSP analyses.
KW - 3D-SSP
KW - Alzheimer's disease
KW - Amyloid imaging
KW - BF-227
KW - Early phase
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U2 - 10.1007/s11604-013-0276-7
DO - 10.1007/s11604-013-0276-7
M3 - Article
C2 - 24408078
AN - SCOPUS:84897469439
SN - 1867-1071
VL - 32
SP - 138
EP - 144
JO - Japanese Journal of Radiology
JF - Japanese Journal of Radiology
IS - 3
ER -