Analysis of multiple primary cancer autopsy cases associated with breast cancer: 2002–2010

Yukiko Shibahara, Yumi Sugawara, Yasuhiro Miki, Shuko Hata, Hiroaki Takahashi, Yasuhiro Nakamura, Takashi Suzuki, Noriaki Ohuchi, Ichiro Tsuji, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Breast cancer patients have a generally increased risk of developing second cancers. The object of this study was to clarify the increased as well as decreased incidence of cancers in breast cancer patients using autopsy cases. 164 211 autopsy cases in the Annual of Pathological Autopsy Cases in Japan from 2002 to 2010 were analyzed for multiple primary cancer (MPC). Female MPC cases (4222 cases) were selected. We investigated the cancer incidence observed in breast cancer associated MPC. The Chi-squared test was used for analysis. All P-values were two-sided, and differences at P < 0.05 were considered significant. Breast cancer associated MPC showed a significantly increased incidence of ovarian, pancreatic, and skin cancer (Odds Ratio [95 % confidence interval (CI)]) = 1.464 [1.03, 2.08], 1.414 [1.08, 1.85] and 2.092 [1.28, 3.41]), and a decreased incidence of colorectal and cervical cancer (OR [95 % CI]) = 0.732 [0.60, 0.90], 0.605 [0.38, 0.96]). Our findings of an increased incidence of malignancies in breast cancer associated MPC cases were consistent with the results of previous population-based studies. This study is the first study to analyze massive autopsy data on MPC which provide new evidence clinically and pathologically.

Original languageEnglish
Pages (from-to)695-700
Number of pages6
JournalPathology international
Issue number12
Publication statusPublished - 2016 Dec 1


  • autopsy
  • breast cancer
  • multiple primary cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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