TY - JOUR
T1 - Analysis of the cutoff values in fibrin-related markers for the diagnosis of overt DIC
AU - Hatada, Tsuyoshi
AU - Wada, Hideo
AU - Kawasugi, Kazuo
AU - Okamoto, Kohji
AU - Uchiyama, Toshimasa
AU - Kushimoto, Shigeki
AU - Seki, Yoshinobu
AU - Okamura, Takashi
AU - Imai, Hiroshi
AU - Kaneko, Toshihiro
AU - Nobori, Tsutomu
N1 - Funding Information:
This prospective study was carried out across 9 institutes, comprising the Department of Molecular and Laboratory Medicine and Emergency Medicine of Mie University School of Medicine, the First Department of Surgery of the University of Occupational and Environmental Health School of Medicine, the Department of Internal Medicine of Takasaki National Hospital, Takasaki, the Department of Internal Medicine of Teikyo University School of Medicine, the Department of Emergency Medicine and Intensive Care of the Graduate School of Medicine, Nagoya University, the Department of Anesthesiology and Critical Care Medicine of Hokkaido University Graduate School of Medicine, the Department of Emergency and Critical Care Medicine of Nippon Medical School, the Department of Internal Medicine of Shibata Hospital-Niigata Prefectural Hospital, the Research Division of Cell and Molecular Medicine of the Center for Molecular Medicine, and the Jichi Medical University School of Medicine. This work was supported in part by a Grant-in-Aid from the Ministry of Health, Labour and Welfare of Japan for Blood Coagulation Abnormalities and from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported in part by a Grant-in-Aid from the Ministry of Health, Labour and Welfare of Japan for Blood Coagulation Abnormalities and from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2012/9
Y1 - 2012/9
N2 - Fibrin-related markers (FRMs) such as fibrin and fibrinogen degradation products (FDPs), d-dimer, and soluble fibrin monomer complex (SFMC) were prospectively evaluated in 522 patients using the overt disseminated intravascular coagulation (DIC) diagnostic criteria. The differences in all FRMs between the DIC group and the non-DIC group, and those between the survivors and nonsurvivors were significant in the patients with infections. In an analysis of all patients, DIC score cutoff values of 2 and 3 points for FDP, d-dimer, and SFMC were recommended to be 8.3 and 42.0 μg/mL, 2.4 and 22.0 μg/mL, and 3.4 and 138.0 μg/mL, respectively. In conclusion, the adequate cutoff value is thus considered to be useful for both making a diagnosis of DIC and for predicting the outcome. Fibrin-related markers are therefore thought to be more useful for making a diagnosis of DIC based on infections than based on any other underlying disorders.
AB - Fibrin-related markers (FRMs) such as fibrin and fibrinogen degradation products (FDPs), d-dimer, and soluble fibrin monomer complex (SFMC) were prospectively evaluated in 522 patients using the overt disseminated intravascular coagulation (DIC) diagnostic criteria. The differences in all FRMs between the DIC group and the non-DIC group, and those between the survivors and nonsurvivors were significant in the patients with infections. In an analysis of all patients, DIC score cutoff values of 2 and 3 points for FDP, d-dimer, and SFMC were recommended to be 8.3 and 42.0 μg/mL, 2.4 and 22.0 μg/mL, and 3.4 and 138.0 μg/mL, respectively. In conclusion, the adequate cutoff value is thus considered to be useful for both making a diagnosis of DIC and for predicting the outcome. Fibrin-related markers are therefore thought to be more useful for making a diagnosis of DIC based on infections than based on any other underlying disorders.
KW - D-dimer
KW - DIC
KW - FDP
KW - fibrin-related markers (FRMs)
KW - soluble fibrin monomer complex (SFMC)
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U2 - 10.1177/1076029611429786
DO - 10.1177/1076029611429786
M3 - Article
C2 - 22203032
AN - SCOPUS:84870890053
SN - 1076-0296
VL - 18
SP - 495
EP - 500
JO - Clinical and Applied Thrombosis/Hemostasis
JF - Clinical and Applied Thrombosis/Hemostasis
IS - 5
ER -