Analysis of the cutoff values in fibrin-related markers for the diagnosis of overt DIC

Tsuyoshi Hatada, Hideo Wada, Kazuo Kawasugi, Kohji Okamoto, Toshimasa Uchiyama, Shigeki Kushimoto, Yoshinobu Seki, Takashi Okamura, Hiroshi Imai, Toshihiro Kaneko, Tsutomu Nobori

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Fibrin-related markers (FRMs) such as fibrin and fibrinogen degradation products (FDPs), d-dimer, and soluble fibrin monomer complex (SFMC) were prospectively evaluated in 522 patients using the overt disseminated intravascular coagulation (DIC) diagnostic criteria. The differences in all FRMs between the DIC group and the non-DIC group, and those between the survivors and nonsurvivors were significant in the patients with infections. In an analysis of all patients, DIC score cutoff values of 2 and 3 points for FDP, d-dimer, and SFMC were recommended to be 8.3 and 42.0 μg/mL, 2.4 and 22.0 μg/mL, and 3.4 and 138.0 μg/mL, respectively. In conclusion, the adequate cutoff value is thus considered to be useful for both making a diagnosis of DIC and for predicting the outcome. Fibrin-related markers are therefore thought to be more useful for making a diagnosis of DIC based on infections than based on any other underlying disorders.

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalClinical and Applied Thrombosis/Hemostasis
Issue number5
Publication statusPublished - 2012 Sept


  • D-dimer
  • DIC
  • FDP
  • fibrin-related markers (FRMs)
  • soluble fibrin monomer complex (SFMC)


Dive into the research topics of 'Analysis of the cutoff values in fibrin-related markers for the diagnosis of overt DIC'. Together they form a unique fingerprint.

Cite this