Analysis of the p53 gene mutations in patients with multiple primary cancers of the oesophagus

Takato Mayama; Takahiro Mori; Keiji Abe; Hironobu Sasano; Tetsuro Nishihira; Susumu Satomi; Akira Horii

doi:10.1016/S0748-7983(97)90642-9

Analysis of the p53 gene mutations in patients with multiple primary cancers of the oesophagus

Takato Mayama, Takahiro Mori, Keiji Abe, Hironobu Sasano, Tetsuro Nishihira, Susumu Satomi, Akira Horii

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

We investigated genetic alterations of the p53 gene in two patients with multiple primary oesophageal squamous cell carcinomas (ESCs). We found that each primary tumour could be distinguished by mutation of p53. Moreover, mutations detected in the p53 gene in metastatic lymph nodes were the same as those detected in at least one of the primary tumours. Our results presented the possibility of: (1) discrimination of primary and metastatic legions in patients with multiple primary ESCs; (2) determination of metastatic pathway to regional lymph nodes; and (3) application for the development of a better clinical management of patients with multiple primary ESCs.

Original language	English
Pages (from-to)	298-303
Number of pages	6
Journal	European Journal of Surgical Oncology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/S0748-7983(97)90642-9
Publication status	Published - 1997

Keywords

Metastasis
Oesophageal multiple cancer
PCR-SSCP
p53

ASJC Scopus subject areas

Surgery
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0748-7983(97)90642-9

Cite this

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title = "Analysis of the p53 gene mutations in patients with multiple primary cancers of the oesophagus",

abstract = "We investigated genetic alterations of the p53 gene in two patients with multiple primary oesophageal squamous cell carcinomas (ESCs). We found that each primary tumour could be distinguished by mutation of p53. Moreover, mutations detected in the p53 gene in metastatic lymph nodes were the same as those detected in at least one of the primary tumours. Our results presented the possibility of: (1) discrimination of primary and metastatic legions in patients with multiple primary ESCs; (2) determination of metastatic pathway to regional lymph nodes; and (3) application for the development of a better clinical management of patients with multiple primary ESCs.",

keywords = "Metastasis, Oesophageal multiple cancer, PCR-SSCP, p53",

author = "Takato Mayama and Takahiro Mori and Keiji Abe and Hironobu Sasano and Tetsuro Nishihira and Susumu Satomi and Akira Horii",

note = "Funding Information: The authors are grateful to Hiromi Shiwaku for her assistance in preparation of the manuscript. This work was supported in part by the Ministry of Education, Science, Sports, and Culture of Japan and by the Vehicle Racing Commemorative Foundation.",

year = "1997",

doi = "10.1016/S0748-7983(97)90642-9",

language = "English",

volume = "23",

pages = "298--303",

journal = "European Journal of Surgical Oncology",

issn = "0748-7983",

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T1 - Analysis of the p53 gene mutations in patients with multiple primary cancers of the oesophagus

AU - Mayama, Takato

AU - Mori, Takahiro

AU - Abe, Keiji

AU - Sasano, Hironobu

AU - Nishihira, Tetsuro

AU - Satomi, Susumu

AU - Horii, Akira

N1 - Funding Information: The authors are grateful to Hiromi Shiwaku for her assistance in preparation of the manuscript. This work was supported in part by the Ministry of Education, Science, Sports, and Culture of Japan and by the Vehicle Racing Commemorative Foundation.

PY - 1997

Y1 - 1997

N2 - We investigated genetic alterations of the p53 gene in two patients with multiple primary oesophageal squamous cell carcinomas (ESCs). We found that each primary tumour could be distinguished by mutation of p53. Moreover, mutations detected in the p53 gene in metastatic lymph nodes were the same as those detected in at least one of the primary tumours. Our results presented the possibility of: (1) discrimination of primary and metastatic legions in patients with multiple primary ESCs; (2) determination of metastatic pathway to regional lymph nodes; and (3) application for the development of a better clinical management of patients with multiple primary ESCs.

AB - We investigated genetic alterations of the p53 gene in two patients with multiple primary oesophageal squamous cell carcinomas (ESCs). We found that each primary tumour could be distinguished by mutation of p53. Moreover, mutations detected in the p53 gene in metastatic lymph nodes were the same as those detected in at least one of the primary tumours. Our results presented the possibility of: (1) discrimination of primary and metastatic legions in patients with multiple primary ESCs; (2) determination of metastatic pathway to regional lymph nodes; and (3) application for the development of a better clinical management of patients with multiple primary ESCs.

KW - Metastasis

KW - Oesophageal multiple cancer

KW - PCR-SSCP

KW - p53

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DO - 10.1016/S0748-7983(97)90642-9

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AN - SCOPUS:0030817586

SN - 0748-7983

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SP - 298

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JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

IS - 4

ER -

Analysis of the p53 gene mutations in patients with multiple primary cancers of the oesophagus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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