Anaplastic multiple myeloma with MYC rearrangement

Satoshi Ichikawa; Noriko Fukuhara; Ko Hashimoto; Fumiyoshi Fujishima; Ryo Ichinohasama; Hideo Harigae

doi:10.1016/j.lrr.2021.100288

Anaplastic multiple myeloma with MYC rearrangement

Satoshi Ichikawa, Noriko Fukuhara, Ko Hashimoto, Fumiyoshi Fujishima, Ryo Ichinohasama, Hideo Harigae

Tohoku University

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Abstract

A 52-year-old man with rapidly progressive paraplegia was presented to us with paravertebral tumors. Laminectomy with tumor resection was performed, and pathological analysis of the tumor revealed compact proliferation of anaplastic plasmacytoid cells. G-band analysis of the tumor revealed a complex karyotype, including IgH/MYC translocation. The patient was diagnosed with anaplastic multiple myeloma (AMM) with MYC arrangement, and cytotoxic chemotherapy followed by autologous hematopoietic stem cell transplantation resulted in long-term disease-free remission. This is the first report describing a case of de novo AMM with MYC rearrangement, suggesting that conventional chemotherapy could be a treatment option for this formidable disease.

Original language	English
Article number	100288
Journal	Leukemia Research Reports
Volume	17
DOIs	https://doi.org/10.1016/j.lrr.2021.100288
Publication status	Published - 2022 Jan

Keywords

1q21 aberration
Anaplastic multiple myeloma
Conventional chemotherapy
MYC rearrangement

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10.1016/j.lrr.2021.100288

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title = "Anaplastic multiple myeloma with MYC rearrangement",

abstract = "A 52-year-old man with rapidly progressive paraplegia was presented to us with paravertebral tumors. Laminectomy with tumor resection was performed, and pathological analysis of the tumor revealed compact proliferation of anaplastic plasmacytoid cells. G-band analysis of the tumor revealed a complex karyotype, including IgH/MYC translocation. The patient was diagnosed with anaplastic multiple myeloma (AMM) with MYC arrangement, and cytotoxic chemotherapy followed by autologous hematopoietic stem cell transplantation resulted in long-term disease-free remission. This is the first report describing a case of de novo AMM with MYC rearrangement, suggesting that conventional chemotherapy could be a treatment option for this formidable disease.",

keywords = "1q21 aberration, Anaplastic multiple myeloma, Conventional chemotherapy, MYC rearrangement",

author = "Satoshi Ichikawa and Noriko Fukuhara and Ko Hashimoto and Fumiyoshi Fujishima and Ryo Ichinohasama and Hideo Harigae",

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doi = "10.1016/j.lrr.2021.100288",

language = "English",

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T1 - Anaplastic multiple myeloma with MYC rearrangement

AU - Ichikawa, Satoshi

AU - Fukuhara, Noriko

AU - Hashimoto, Ko

AU - Fujishima, Fumiyoshi

AU - Ichinohasama, Ryo

AU - Harigae, Hideo

PY - 2022/1

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N2 - A 52-year-old man with rapidly progressive paraplegia was presented to us with paravertebral tumors. Laminectomy with tumor resection was performed, and pathological analysis of the tumor revealed compact proliferation of anaplastic plasmacytoid cells. G-band analysis of the tumor revealed a complex karyotype, including IgH/MYC translocation. The patient was diagnosed with anaplastic multiple myeloma (AMM) with MYC arrangement, and cytotoxic chemotherapy followed by autologous hematopoietic stem cell transplantation resulted in long-term disease-free remission. This is the first report describing a case of de novo AMM with MYC rearrangement, suggesting that conventional chemotherapy could be a treatment option for this formidable disease.

AB - A 52-year-old man with rapidly progressive paraplegia was presented to us with paravertebral tumors. Laminectomy with tumor resection was performed, and pathological analysis of the tumor revealed compact proliferation of anaplastic plasmacytoid cells. G-band analysis of the tumor revealed a complex karyotype, including IgH/MYC translocation. The patient was diagnosed with anaplastic multiple myeloma (AMM) with MYC arrangement, and cytotoxic chemotherapy followed by autologous hematopoietic stem cell transplantation resulted in long-term disease-free remission. This is the first report describing a case of de novo AMM with MYC rearrangement, suggesting that conventional chemotherapy could be a treatment option for this formidable disease.

KW - 1q21 aberration

KW - Anaplastic multiple myeloma

KW - Conventional chemotherapy

KW - MYC rearrangement

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JO - Leukemia Research Reports

JF - Leukemia Research Reports

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Anaplastic multiple myeloma with MYC rearrangement

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Keywords

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