@inproceedings{12cdd4d57cec45e28d63e19ee8bfd42d,
title = "Angiogenesis derived from shear stress optimised by a microfruidic device",
abstract = "Previously, we created a 3D vascular network in a microfluidic device and demonstrated that the luminal flow significantly enhanced the formation of angiogenic sprouts as compared to static conditions [1]. These results could not be explained based on either biochemical factors (oxygen and nutrient transport) or mechanical factors (pressure and shear stress) derived angiogenesis. In this study, we investigated the effect of flow rate and shear stress on angiogenesis induced by luminal flow. We calculated the shear stress exposed on the endothelium where new sprouting initiated. Our results showed that angiogenesis was induced in the specific range of shear stress.",
keywords = "Angiogenesis, Microfluidic device, Shear stress, Vascular networks",
author = "Yukako Teraoka and Masamune Nakayama and Yuji Nashimoto and Akiko Nakamasu and Sanshiro Hanada and Yuichiro Arima and Torisawa, {Yu Suke} and Hidetoshi Kotera and Koichi Nishiyama and Takashi Miura and Ryuji Yokokawa",
note = "Funding Information: This work was supported by CREST, Japan Science and Technology Agency (JST). Publisher Copyright: {\textcopyright} 17CBMS-0001.; 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",
year = "2020",
language = "English",
series = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
publisher = "Chemical and Biological Microsystems Society",
pages = "1072--1073",
booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
}