Angiopoietin-3, a novel member of the angiopoietin family

Motoi Nishimura; Takashi Miki; Rei Yashima; Norihide Yokoi; Hideki Yano; Yasufumi Sato; Susumu Seino

doi:10.1016/S0014-5793(99)00381-6

Angiopoietin-3, a novel member of the angiopoietin family

Motoi Nishimura, Takashi Miki, Rei Yashima, Norihide Yokoi, Hideki Yano, Yasufumi Sato, Susumu Seino

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	254-256
Number of pages	3
Journal	FEBS Letters
Volume	448
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-5793(99)00381-6
Publication status	Published - 1999 Apr 9
Externally published	Yes

Keywords

Angiogenesis
Angiopoietin
Tie
Vascular endothelial growth factor

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(99)00381-6

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title = "Angiopoietin-3, a novel member of the angiopoietin family",

abstract = "A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2. Copyright (C) 1999 Federation of European Biochemical Societies.",

keywords = "Angiogenesis, Angiopoietin, Tie, Vascular endothelial growth factor",

author = "Motoi Nishimura and Takashi Miki and Rei Yashima and Norihide Yokoi and Hideki Yano and Yasufumi Sato and Susumu Seino",

note = "Funding Information: We thank N. Mitsuhashi and H. Kasai for technical assistance. This work was supported by Research on Human Genome and Gene Therapy from the Ministry of Health and Welfare, Japan; by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture, Japan; by a grant for studies on the pathophysiology and complications of diabetes from Tsumura Pharma Ltd.",

year = "1999",

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doi = "10.1016/S0014-5793(99)00381-6",

language = "English",

volume = "448",

pages = "254--256",

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T1 - Angiopoietin-3, a novel member of the angiopoietin family

AU - Nishimura, Motoi

AU - Miki, Takashi

AU - Yashima, Rei

AU - Yokoi, Norihide

AU - Yano, Hideki

AU - Sato, Yasufumi

AU - Seino, Susumu

N1 - Funding Information: We thank N. Mitsuhashi and H. Kasai for technical assistance. This work was supported by Research on Human Genome and Gene Therapy from the Ministry of Health and Welfare, Japan; by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture, Japan; by a grant for studies on the pathophysiology and complications of diabetes from Tsumura Pharma Ltd.

PY - 1999/4/9

Y1 - 1999/4/9

N2 - A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2. Copyright (C) 1999 Federation of European Biochemical Societies.

AB - A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2. Copyright (C) 1999 Federation of European Biochemical Societies.

KW - Angiogenesis

KW - Angiopoietin

KW - Tie

KW - Vascular endothelial growth factor

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JO - FEBS Letters

JF - FEBS Letters

IS - 2-3

ER -

Angiopoietin-3, a novel member of the angiopoietin family

Abstract

Keywords

ASJC Scopus subject areas

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