Background: Anti-agalactosyl immunoglobulin G (IgG) antibodies (anti-AG IgG) have been reported to be detected and correlated with disease activity in some collagen diseases. Method: Forty-seven serum samples from patients with localized scleroderma were examined using an enzyme-linked immunosorbent assay. Results: Anti-AG IgG were positive in 19% of patients with localized scleroderma. The frequency of anti-AG IgG in generalized morphea was much higher than that in linear scleroderma or that in morphea.There was a significant correlation between anti-AG IgG levels and the number of the sclerotic lesions and between anti-AG IgG levels and the number of involved areas. The levels of anti-AG IgG were significantly higher in patients with antinuclear antibody, antisingle-stranded DNA antibody or rheumatoid factor than in those without. Conclusion: Anti-AG IgG can be an indicator of the severity of localized scleroderma.
|Number of pages||4|
|Journal||International Journal of Dermatology|
|Publication status||Published - 2005 Oct|
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