Anti-agalactosyl immunoglobulin G antibodies in localized scleroderma

Yoshihiro Mimura; Hronobu Ihn; Masatoshi Jinnin; Yoshihide Asano; Kenichi Yamane; Norihito Yazawa; Kunihiko Tamaki

doi:10.1111/j.1365-4632.2005.02584.x

Anti-agalactosyl immunoglobulin G antibodies in localized scleroderma

Yoshihiro Mimura, Hronobu Ihn, Masatoshi Jinnin, Yoshihide Asano, Kenichi Yamane, Norihito Yazawa, Kunihiko Tamaki

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background: Anti-agalactosyl immunoglobulin G (IgG) antibodies (anti-AG IgG) have been reported to be detected and correlated with disease activity in some collagen diseases. Method: Forty-seven serum samples from patients with localized scleroderma were examined using an enzyme-linked immunosorbent assay. Results: Anti-AG IgG were positive in 19% of patients with localized scleroderma. The frequency of anti-AG IgG in generalized morphea was much higher than that in linear scleroderma or that in morphea.There was a significant correlation between anti-AG IgG levels and the number of the sclerotic lesions and between anti-AG IgG levels and the number of involved areas. The levels of anti-AG IgG were significantly higher in patients with antinuclear antibody, antisingle-stranded DNA antibody or rheumatoid factor than in those without. Conclusion: Anti-AG IgG can be an indicator of the severity of localized scleroderma.

Original language	English
Pages (from-to)	817-820
Number of pages	4
Journal	International Journal of Dermatology
Volume	44
Issue number	10
DOIs	https://doi.org/10.1111/j.1365-4632.2005.02584.x
Publication status	Published - 2005 Oct
Externally published	Yes

ASJC Scopus subject areas

Dermatology

Access to Document

10.1111/j.1365-4632.2005.02584.x

Cite this

@article{11b6b26095f14578a6ee04bf71f6819e,

title = "Anti-agalactosyl immunoglobulin G antibodies in localized scleroderma",

abstract = "Background: Anti-agalactosyl immunoglobulin G (IgG) antibodies (anti-AG IgG) have been reported to be detected and correlated with disease activity in some collagen diseases. Method: Forty-seven serum samples from patients with localized scleroderma were examined using an enzyme-linked immunosorbent assay. Results: Anti-AG IgG were positive in 19% of patients with localized scleroderma. The frequency of anti-AG IgG in generalized morphea was much higher than that in linear scleroderma or that in morphea.There was a significant correlation between anti-AG IgG levels and the number of the sclerotic lesions and between anti-AG IgG levels and the number of involved areas. The levels of anti-AG IgG were significantly higher in patients with antinuclear antibody, antisingle-stranded DNA antibody or rheumatoid factor than in those without. Conclusion: Anti-AG IgG can be an indicator of the severity of localized scleroderma.",

author = "Yoshihiro Mimura and Hronobu Ihn and Masatoshi Jinnin and Yoshihide Asano and Kenichi Yamane and Norihito Yazawa and Kunihiko Tamaki",

year = "2005",

month = oct,

doi = "10.1111/j.1365-4632.2005.02584.x",

language = "English",

volume = "44",

pages = "817--820",

journal = "International Journal of Dermatology",

issn = "0011-9059",

publisher = "Wiley-Blackwell",

number = "10",

}

TY - JOUR

T1 - Anti-agalactosyl immunoglobulin G antibodies in localized scleroderma

AU - Mimura, Yoshihiro

AU - Ihn, Hronobu

AU - Jinnin, Masatoshi

AU - Asano, Yoshihide

AU - Yamane, Kenichi

AU - Yazawa, Norihito

AU - Tamaki, Kunihiko

PY - 2005/10

Y1 - 2005/10

N2 - Background: Anti-agalactosyl immunoglobulin G (IgG) antibodies (anti-AG IgG) have been reported to be detected and correlated with disease activity in some collagen diseases. Method: Forty-seven serum samples from patients with localized scleroderma were examined using an enzyme-linked immunosorbent assay. Results: Anti-AG IgG were positive in 19% of patients with localized scleroderma. The frequency of anti-AG IgG in generalized morphea was much higher than that in linear scleroderma or that in morphea.There was a significant correlation between anti-AG IgG levels and the number of the sclerotic lesions and between anti-AG IgG levels and the number of involved areas. The levels of anti-AG IgG were significantly higher in patients with antinuclear antibody, antisingle-stranded DNA antibody or rheumatoid factor than in those without. Conclusion: Anti-AG IgG can be an indicator of the severity of localized scleroderma.

AB - Background: Anti-agalactosyl immunoglobulin G (IgG) antibodies (anti-AG IgG) have been reported to be detected and correlated with disease activity in some collagen diseases. Method: Forty-seven serum samples from patients with localized scleroderma were examined using an enzyme-linked immunosorbent assay. Results: Anti-AG IgG were positive in 19% of patients with localized scleroderma. The frequency of anti-AG IgG in generalized morphea was much higher than that in linear scleroderma or that in morphea.There was a significant correlation between anti-AG IgG levels and the number of the sclerotic lesions and between anti-AG IgG levels and the number of involved areas. The levels of anti-AG IgG were significantly higher in patients with antinuclear antibody, antisingle-stranded DNA antibody or rheumatoid factor than in those without. Conclusion: Anti-AG IgG can be an indicator of the severity of localized scleroderma.

UR - http://www.scopus.com/inward/record.url?scp=27544509850&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27544509850&partnerID=8YFLogxK

U2 - 10.1111/j.1365-4632.2005.02584.x

DO - 10.1111/j.1365-4632.2005.02584.x

M3 - Article

C2 - 16207181

AN - SCOPUS:27544509850

SN - 0011-9059

VL - 44

SP - 817

EP - 820

JO - International Journal of Dermatology

JF - International Journal of Dermatology

IS - 10

ER -

Anti-agalactosyl immunoglobulin G antibodies in localized scleroderma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this