Anti-agalactosyl immunoglobulin G antibodies in localized scleroderma

Yoshihiro Mimura, Hronobu Ihn, Masatoshi Jinnin, Yoshihide Asano, Kenichi Yamane, Norihito Yazawa, Kunihiko Tamaki

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10 Citations (Scopus)


Background: Anti-agalactosyl immunoglobulin G (IgG) antibodies (anti-AG IgG) have been reported to be detected and correlated with disease activity in some collagen diseases. Method: Forty-seven serum samples from patients with localized scleroderma were examined using an enzyme-linked immunosorbent assay. Results: Anti-AG IgG were positive in 19% of patients with localized scleroderma. The frequency of anti-AG IgG in generalized morphea was much higher than that in linear scleroderma or that in morphea.There was a significant correlation between anti-AG IgG levels and the number of the sclerotic lesions and between anti-AG IgG levels and the number of involved areas. The levels of anti-AG IgG were significantly higher in patients with antinuclear antibody, antisingle-stranded DNA antibody or rheumatoid factor than in those without. Conclusion: Anti-AG IgG can be an indicator of the severity of localized scleroderma.

Original languageEnglish
Pages (from-to)817-820
Number of pages4
JournalInternational Journal of Dermatology
Issue number10
Publication statusPublished - 2005 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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