Anti-angiogenic activity of tocotrienol

Hitoshi Inokuchi; Hisako Hirokane; Tsuyoshi Tsuzuki; Kiyotaka Nakagawa; Miki Igarashi; Teruo Miyazawa

doi:10.1271/bbb.67.1623

Anti-angiogenic activity of tocotrienol

Hitoshi Inokuchi, Hisako Hirokane, Tsuyoshi Tsuzuki, Kiyotaka Nakagawa, Miki Igarashi, Teruo Miyazawa

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with δ-tocotrienol appearing the highest activity. Also, δ-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.

Original language	English
Pages (from-to)	1623-1627
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	67
Issue number	7
DOIs	https://doi.org/10.1271/bbb.67.1623
Publication status	Published - 2003 Jan 1

Keywords

Angiogenesis inhibitor
Cancer
Tocopherol
Tocotrienol
Vitamin E

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.67.1623

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T1 - Anti-angiogenic activity of tocotrienol

AU - Inokuchi, Hitoshi

AU - Hirokane, Hisako

AU - Tsuzuki, Tsuyoshi

AU - Nakagawa, Kiyotaka

AU - Igarashi, Miki

AU - Miyazawa, Teruo

PY - 2003/1/1

Y1 - 2003/1/1

N2 - The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with δ-tocotrienol appearing the highest activity. Also, δ-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.

AB - The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with δ-tocotrienol appearing the highest activity. Also, δ-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.

KW - Angiogenesis inhibitor

KW - Cancer

KW - Tocopherol

KW - Tocotrienol

KW - Vitamin E

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EP - 1627

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 7

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Anti-angiogenic activity of tocotrienol

Abstract

Keywords

UN SDGs

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