Anti-angiogenic activity of tocotrienol

Hitoshi Inokuchi, Hisako Hirokane, Tsuyoshi Tsuzuki, Kiyotaka Nakagawa, Miki Igarashi, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)


The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with δ-tocotrienol appearing the highest activity. Also, δ-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.

Original languageEnglish
Pages (from-to)1623-1627
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Issue number7
Publication statusPublished - 2003 Jan 1


  • Angiogenesis inhibitor
  • Cancer
  • Tocopherol
  • Tocotrienol
  • Vitamin E


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