Anti-angiogenic drugs

Research output: Contribution to journalArticlepeer-review


Angiogenesis, the formation of neo-vessels, is a physiological event but is involved in various pathological conditions including cancers. Thus, the establishment of effective anti-angiogenic treatment has long been a goal. The recent development of bevacizumab, a neutralizing monoclonal antibody against VEGF, as the first anti-angiogenic drug, validated the clinical benefit of the inhibition of tumor angiogenesis. Thereafter, various drugs targeting VEGF-mediated signals have been developed to control tumor angiogenesis. Anti-angiogenic therapy is now considered a major step forward in cancer treatment at the clinical level.

Original languageEnglish
Pages (from-to)1072-1075
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Issue number7
Publication statusPublished - 2009 Jul


  • HIF-1
  • mTOR
  • VEGF
  • VEGFR2


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