1. We evaluated the antianginal effects of YM430 in several experimental models in vitro and in vivo. 2. In isolated dog. coronary artery, YM430 (10-8-10-6 M) inhibited 3,4 diaminopyridine induced rhythmic contractions with an IC50 value of 59.2 nM. 3. In anesthetized rats, YM430 (10-100 mg/kg PO) inhibited arginine vasopressin-induced ST-segment depression with an IC50 value of 36.6 mg/kg PO. 4. In anesthetized dogs, YM430 (0.3 mg/kg IV) significantly inhibited ST-segment elevation induced by coronary artery occlusion. 5. These findings suggest that YM430 may be of value in the treatment of various types of angina pectoris such as variant and stable angina.
|Number of pages||6|
|Publication status||Published - 1997 Oct|
- Calcium antagonist
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