Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol)

Teruo Miyazawa, Akira Shibata, Phumon Sookwong, Yuki Kawakami, Takahiro Eitsuka, Akira Asai, Shinichi Oikawa, Kiyotaka Nakagawa

Research output: Contribution to journalReview articlepeer-review

103 Citations (Scopus)


Several lines of evidence support the beneficial effect of tocotrienol (T3; an unsaturated vitamin E) on inhibition of tumor development. Many factors, including decrease in oxidative stress and modulation of cell signaling pathways in tumor and endothelial cells, have been implicated in such anticancer action of T3, while the in vivo potency and exact intracellular mechanisms for the anticancer properties of T3 remain not fully understood. We have hypothesized that the inhibitory effect of T3 on cancer may be attributable to the antiangiogenic activity of T3, and we found that T3 acts as a potent regulator of growth-factor-dependent signaling in endothelial cells and as an antiangiogenic agent minimizing tumor growth. In this work, we review the history and biological action (i.e., anticancer) of vitamin E and describe current research on the antiangiogenic effects of T3 and its mechanisms.

Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalJournal of Nutritional Biochemistry
Issue number2
Publication statusPublished - 2009 Feb


  • Antiangiogenesis
  • Endothelial cells
  • Tocotrienol
  • Tumor
  • Vitamin E

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry


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