Antibacterial effect of thiocyanate substituted poly(vinyl chloride)

Tomohito Kameda, Masahiko Ono, Guido Grause, Tadaaki Mizoguchi, Toshiaki Yoshioka

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Poly(vinyl chloride) (PVC) modified in different solvents by nucleophilic substitution with thiocyanate was exposed to Gram-negative bacteria of the strain Staphylococcus capitis. All modified pieces reduced the adhesion of bacteria by between 67 and 79%. More important for the bacteria suppression than the substitution rate was the ratio between thiocyanate and isothiocyanate groups. The best result was obtained with PVC modified in tetrahydrofuran/ dimethylsulfoxide, containing only antibacterial active isothiocyanate groups, while inactive thiocyanate groups were absent.

Original languageEnglish
Pages (from-to)945-947
Number of pages3
JournalJournal of Polymer Research
Issue number5
Publication statusPublished - 2011 Sept


  • Bacterial adhesion
  • Nucleophilic substitution: Thiocyanate
  • Poly(vinyl chloride)


Dive into the research topics of 'Antibacterial effect of thiocyanate substituted poly(vinyl chloride)'. Together they form a unique fingerprint.

Cite this