Antibacterial properties of Cu-doped TiO2 prepared by chemical and heat treatment of Ti metal

Kanae Suzuki, Taishi Yokoi, Misato Iwatsu, Maiko Furuya, Kotone Yokota, Takayuki Mokudai, Hiroyasu Kanetaka, Masakazu Kawashita

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8 Citations (Scopus)


In this study, we proposed Cu-doped TiO2, prepared by the alkaline and heat treatment of titanium (Ti) metal, for use in dental applications because of its bone-bonding and antibacterial properties generated by the release of Cu ions and visible-light-responsive photocatalysis. We successfully prepared Cu-doped TiO2 on a Ti chip surface with a Cu content of 7 at.%. The apatite-forming ability of the Cu-doped TiO2 was evaluated using a simulated body fluid and it was found that apatite formation occurred. Hence, we concluded that Cu-doped TiO2 exhibits bone-bonding properties. The antibacterial properties of Cu-doped TiO2 for Escherichia coli were higher than those of non-doped TiO2 under visible light irradiation. The enhanced antibacterial effect was mainly caused by the visible-light-responsive photocatalysis of Cu-doped TiO2. We confirmed that the reactive oxygen species generated by the visible-light-responsive photocatalysis of Cu-doped TiO2 were hydroxyl radicals formed by the reaction of hydroxide ions (OH) and holes (h+). Our findings are useful for the development of novel bioactive TiO2-based coatings and bulk materials with antibacterial properties by Cu doping.

Original languageEnglish
Pages (from-to)1448-1456
Number of pages9
JournalJournal of Asian Ceramic Societies
Issue number4
Publication statusPublished - 2021


  • antibacterial properties
  • bone-bonding property
  • copper doping
  • Titanium dioxide
  • visible-light-responsive photocatalysis


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