Antihypertensive drug prescription trends for pregnant women with hypertension in acute hospitals in Japan

Daisuke Kikuchi; Taku Obara; Ryosuke Miura; Naoto Suzuki; Hiroyuki Hirakawa; Risa Josaka; Misato Ito; Misaki Tokunaga; Kensuke Usui; Kouji Okada

doi:10.1038/s41440-022-00956-7

Antihypertensive drug prescription trends for pregnant women with hypertension in acute hospitals in Japan

Daisuke Kikuchi, Taku Obara, Ryosuke Miura, Naoto Suzuki, Hiroyuki Hirakawa, Risa Josaka, Misato Ito, Misaki Tokunaga, Kensuke Usui, Kouji Okada

Tohoku Medical Megabank Organization (ToMMo)

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Hypertensive disorders of pregnancy cause maternal organ damage. Therefore, appropriate management with antihypertensive medication is required from the first trimester. We aimed to clarify the antihypertensive drug prescription trends in pregnant women with hypertension in Japan. The administrative data of pregnant outpatients aged 16–49 years who visited acute hospitals between 2013 and 2020 were included. The annual antihypertensive drug prescription trends were evaluated based on their prescription proportions. The most prescribed drug in 2020 was nifedipine, followed by methyldopa and amlodipine. The proportion of nifedipine prescriptions significantly increased from 33.5 to 40.8% during the study period, whereas that of methyldopa significantly decreased from 16.6 to 11.6%. There was no change in the prescription trend of amlodipine. Dihydropyridine calcium channel blockers were the most commonly prescribed drug for pregnant women with hypertension.

Original language	English
Pages (from-to)	1441-1446
Number of pages	6
Journal	Hypertension Research
Volume	45
Issue number	9
DOIs	https://doi.org/10.1038/s41440-022-00956-7
Publication status	Published - 2022 Sept

Keywords

Administrative database
Antihypertensive drug
Pregnant women
Prescription
The Japanese Society of Hypertension (JSH) guidelines

ASJC Scopus subject areas

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

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10.1038/s41440-022-00956-7

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title = "Antihypertensive drug prescription trends for pregnant women with hypertension in acute hospitals in Japan",

abstract = "Hypertensive disorders of pregnancy cause maternal organ damage. Therefore, appropriate management with antihypertensive medication is required from the first trimester. We aimed to clarify the antihypertensive drug prescription trends in pregnant women with hypertension in Japan. The administrative data of pregnant outpatients aged 16–49 years who visited acute hospitals between 2013 and 2020 were included. The annual antihypertensive drug prescription trends were evaluated based on their prescription proportions. The most prescribed drug in 2020 was nifedipine, followed by methyldopa and amlodipine. The proportion of nifedipine prescriptions significantly increased from 33.5 to 40.8% during the study period, whereas that of methyldopa significantly decreased from 16.6 to 11.6%. There was no change in the prescription trend of amlodipine. Dihydropyridine calcium channel blockers were the most commonly prescribed drug for pregnant women with hypertension.",

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AU - Kikuchi, Daisuke

AU - Obara, Taku

AU - Miura, Ryosuke

AU - Suzuki, Naoto

AU - Hirakawa, Hiroyuki

AU - Josaka, Risa

AU - Ito, Misato

AU - Tokunaga, Misaki

AU - Usui, Kensuke

AU - Okada, Kouji

N1 - Funding Information: We would like to thank Editage (www.editage.com) for writing support. Publisher Copyright: © 2022, The Author(s), under exclusive licence to The Japanese Society of Hypertension.

PY - 2022/9

Y1 - 2022/9

N2 - Hypertensive disorders of pregnancy cause maternal organ damage. Therefore, appropriate management with antihypertensive medication is required from the first trimester. We aimed to clarify the antihypertensive drug prescription trends in pregnant women with hypertension in Japan. The administrative data of pregnant outpatients aged 16–49 years who visited acute hospitals between 2013 and 2020 were included. The annual antihypertensive drug prescription trends were evaluated based on their prescription proportions. The most prescribed drug in 2020 was nifedipine, followed by methyldopa and amlodipine. The proportion of nifedipine prescriptions significantly increased from 33.5 to 40.8% during the study period, whereas that of methyldopa significantly decreased from 16.6 to 11.6%. There was no change in the prescription trend of amlodipine. Dihydropyridine calcium channel blockers were the most commonly prescribed drug for pregnant women with hypertension.

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Antihypertensive drug prescription trends for pregnant women with hypertension in acute hospitals in Japan

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Keywords

ASJC Scopus subject areas

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