Antihypertensive drug prescription trends for pregnant women with hypertension in acute hospitals in Japan

Daisuke Kikuchi, Taku Obara, Ryosuke Miura, Naoto Suzuki, Hiroyuki Hirakawa, Risa Josaka, Misato Ito, Misaki Tokunaga, Kensuke Usui, Kouji Okada

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Hypertensive disorders of pregnancy cause maternal organ damage. Therefore, appropriate management with antihypertensive medication is required from the first trimester. We aimed to clarify the antihypertensive drug prescription trends in pregnant women with hypertension in Japan. The administrative data of pregnant outpatients aged 16–49 years who visited acute hospitals between 2013 and 2020 were included. The annual antihypertensive drug prescription trends were evaluated based on their prescription proportions. The most prescribed drug in 2020 was nifedipine, followed by methyldopa and amlodipine. The proportion of nifedipine prescriptions significantly increased from 33.5 to 40.8% during the study period, whereas that of methyldopa significantly decreased from 16.6 to 11.6%. There was no change in the prescription trend of amlodipine. Dihydropyridine calcium channel blockers were the most commonly prescribed drug for pregnant women with hypertension.

Original languageEnglish
Pages (from-to)1441-1446
Number of pages6
JournalHypertension Research
Issue number9
Publication statusPublished - 2022 Sept


  • Administrative database
  • Antihypertensive drug
  • Pregnant women
  • Prescription
  • The Japanese Society of Hypertension (JSH) guidelines

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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