Antimicrobial activity of tea catechin against canine oral bacteria and the functional mechanisms

Lanlan Bai, Shiaki Takagi, Tasuke Ando, Hiroshi Yoneyama, Kumiko Ito, Hiroyuki Mizugai, Emiko Isogai

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Epigallocatechin gallate (EGCG) is the major polyphenolic compound of green tea. Polyphenolic compounds were extracted from the leaf of Camellia sinensis (Japanese green tea), and the minimum inhibitory concentration against canine oral bacteria was measured. Subsequently, we investigated the inhibitory effects of polyphenolic compounds and EGCG on the growth of canine oral bacteria. EGCG showed antimicrobial activity against a model bacterium, Streptococcus mutans. Our results indicate that EGCG can inhibit the growth and biofilm formation of S. mutans and that EGCG does not interact with streptococcal lipoteichoic acid (LTA). Furthermore, our findings suggest that EGCG interacts with other component(s) of the bacterial membrane aside from streptococcal LTA to inhibit biofilm formation and damage biofilms.

Original languageEnglish
Pages (from-to)1439-1445
Number of pages7
JournalJournal of Veterinary Medical Science
Issue number9
Publication statusPublished - 2016 Sept


  • Biofilm
  • EGCG
  • Polyphenolic compounds
  • Streptococcal lipoteichoic acid


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