@article{08e87a87e7ca43918190b1f140f2e904,
title = "Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist",
abstract = "We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons. (C) 2000 Elsevier Science B.V.",
keywords = "Calcium channel, Cilnidipine, Nociception",
author = "Manabu Murakami and Osamu Nakagawasai and Shigeo Fujii and Masahiro Hosono and Soichi Hozumi and Akihisa Esashi and Ryoo Taniguchi and Tadashi Okamura and Takashi Suzuki and Hironobu Sasano and Teruyuki Yanagisawa and Koichi Tan-No and Takeshi Tadano and Kenji Kitamura and Kensuke Kisara",
note = "Funding Information: We thank Mrs. Tetsuko Sueta and Mrs. Agnieszka Murakami for technical assistance, We also thank Dr. Kazuo Nunoki and Mr. Brant Bell for critically reading the manuscript. We also thank Boehringer Ingelheim Co. for their help. This research was supported by grants-in-aid from the Ministry of Education, Science and Culture.",
year = "2000",
month = jun,
day = "16",
doi = "10.1016/S0006-8993(00)02295-2",
language = "English",
volume = "868",
pages = "123--127",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",
}