Antioxidant Effects of Caesalpinia paraensis Extract on Human Skin Lipid Peroxidation

Keita Someya, Hiroyuki Shimizu, Chiyoko Uchiyama, Ichiro Nakajima, Tatsuo Hayashi, Koji Takada, Masanori Kuroyanagi, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


To confirm the antioxidant effects of the extract taken from Caesalpinia paraensis (ECP), we conducted various oxidation tests where the efficacy of this extract was compared to tocopherol (Toc) and ascorbic acid (AsA). We also evaluated the antioxidant effects of ECP on human-skin-lipid peroxidation using a chemiluminescence-HPLC (CL-HPLC) method. The ECP exhibited moderate antioxidant effectiveness in the conductometric determination method (CDM) test and oven test, which we carried out in homogeneous solution systems. In the β-carotene decoloring tests, which were heterogeneous systems, ECP had a strong antioxidant effect in both lipophilic and hydrophilic radical generation systems. In the singlet oxygen generating test, the ECP demonstrated very weak antioxidant properties. Furthermore, the topical application of ECP (at a concentration of 0.1 %) significantly suppressed the increase in the squalene monohydroperoxide (SqOOH)/squalene (Sq) ratios in human skin after UV irradiation. The ECP demonstrated various antioxidant effects, especially superior efficacy in the heterogeneous systems. Human skin consists of polyphasic systems. Therefore, we consider that the ECP could effectively prevent the skin lipid peroxidation caused by UV irradiation.

Original languageEnglish
Pages (from-to)463-470
Number of pages8
JournalJournal of Oleo Science
Issue number9
Publication statusPublished - 2003


  • antioxidant
  • Caesalpinia paraensis
  • peroxidation
  • polyphenol
  • skin lipid


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