Antiproteinuric effects of renin–angiotensin inhibitors in lung cancer patients receiving bevacizumab

Satoru Nihei, Junya Sato, Toshiyuki Harada, Shoichi Kuyama, Toshiro Suzuki, Nobutsugu Waga, Yoshitaka Saito, Shigeki Kisara, Atsuko Yokota, Kouji Okada, Masami Tsuchiya, Kazufumi Terui, Yumiko Tadokoro, Takeshi Chiba, Kenzo Kudo, Satoshi Oizumi, Akira Inoue, Naoto Morikawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Purpose: The objective of this study was to investigate the effect of renin–angiotensin system inhibitors (RASIs) on bevacizumab (BV)-induced proteinuria in non-small cell lung cancer (NSCLC) patients. Materials and methods: We retrospectively reviewed the medical records of NSCLC patients receiving BV between 2008 and 2014 at 11 hospitals. The patients were categorized into three groups according to their antihypertensive drug use: RASI user, non-RASI user, and non-user groups. The primary outcome was a proteinuria event of any grade during the first 6 cycles of BV treatment. Results: A total of 211 patients were included, 89 of whom received antihypertensive drugs. Of these 89 patients, 49 were in the RASI user group, and 40 were in the non-RASI user group. The non-user group comprised 122 patients. The occurrence of proteinuria in the RASI user group was significantly lower than that in the non-RASI user group (P = 0.037) but was not significantly lower than that in the non-user group (P = 0.287). Patients using RASIs had a lower rate of proteinuria than those who did not use RASIs according to multivariate analysis (odds ratio 0.32; 95% confidence interval 0.12–0.86; P = 0.024). Conclusion: Our study suggests that RASI administration reduces the risk of proteinuria in patients receiving BV.

Original languageEnglish
Pages (from-to)1051-1059
Number of pages9
JournalCancer Chemotherapy and Pharmacology
Issue number6
Publication statusPublished - 2018 Jun 1


  • Bevacizumab
  • Non-small cell lung cancer
  • Proteinuria
  • Renin–angiotensin system inhibitor


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