Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica

Yong Li; Zhi Yu Ni; Meng Chu Zhu; Mei Dong; Si Ming Wang; Qing Wen Shi; Man Li Zhang; Yu Fang Wang; Chang Hong Huo; Hiromasa Kiyota; Bin Cong

doi:10.1515/znc-2012-7-804

Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica

Yong Li, Zhi Yu Ni, Meng Chu Zhu, Mei Dong, Si Ming Wang, Qing Wen Shi, Man Li Zhang, Yu Fang Wang, Chang Hong Huo, Hiromasa Kiyota, Bin Cong

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Eight sesquiterpene lactones were isolated from the roots of Inula helenium and flowers of I. japonica. Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC₅₀ ≤ 100 μM). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an α-exomethylene-γ-lactone ring is necessary for these activities.

Original language	English
Pages (from-to)	375-380
Number of pages	6
Journal	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume	67 C
Issue number	7-8
DOIs	https://doi.org/10.1515/znc-2012-7-804
Publication status	Published - 2012

Keywords

Antitumour activity
Inula sp.
Sesquiterpenes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/znc-2012-7-804

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title = "Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica",

abstract = "Eight sesquiterpene lactones were isolated from the roots of Inula helenium and flowers of I. japonica. Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 ≤ 100 μM). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an α-exomethylene-γ-lactone ring is necessary for these activities.",

keywords = "Antitumour activity, Inula sp., Sesquiterpenes",

author = "Yong Li and Ni, {Zhi Yu} and Zhu, {Meng Chu} and Mei Dong and Wang, {Si Ming} and Shi, {Qing Wen} and Zhang, {Man Li} and Wang, {Yu Fang} and Huo, {Chang Hong} and Hiromasa Kiyota and Bin Cong",

year = "2012",

doi = "10.1515/znc-2012-7-804",

language = "English",

volume = "67 C",

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T1 - Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica

AU - Li, Yong

AU - Ni, Zhi Yu

AU - Zhu, Meng Chu

AU - Dong, Mei

AU - Wang, Si Ming

AU - Shi, Qing Wen

AU - Zhang, Man Li

AU - Wang, Yu Fang

AU - Huo, Chang Hong

AU - Kiyota, Hiromasa

AU - Cong, Bin

PY - 2012

Y1 - 2012

N2 - Eight sesquiterpene lactones were isolated from the roots of Inula helenium and flowers of I. japonica. Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 ≤ 100 μM). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an α-exomethylene-γ-lactone ring is necessary for these activities.

AB - Eight sesquiterpene lactones were isolated from the roots of Inula helenium and flowers of I. japonica. Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 ≤ 100 μM). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an α-exomethylene-γ-lactone ring is necessary for these activities.

KW - Antitumour activity

KW - Inula sp.

KW - Sesquiterpenes

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JO - Zeitschrift fur Naturforschung. Section C: Biosciences

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ER -

Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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