Apatite-forming ability of glass-ceramics containing whitlockite and diopside in a simulated body fluid

Masanobu Kamitakahara, Chikara Ohtsuki, Yuko Kozaka, Masao Tanihara, Toshiki Miyazaki

Research output: Contribution to journalArticlepeer-review


Tricalcium phosphate (SCaO·P2O5, TCP) is known as a biodegradable material and already used clinically as important bone-repairing materials. However, the control of its bone-bonding ability, i.e. bioactivity, and biodegradability is not easy. On the other hand, diopside (CaO·MgO·2SiO2) ceramic shows a potential of direct contact with bone and high mechanical strength, but low biodegradability. We expected that a glass-ceramic containing TCP and diopside show high bioactivity and high mechanical strength, as well as biodegradability. Glasses with composition x(3CaO·P2O5)·(100-x) (CaO·MgO·2SiO2) (x = 0, 38, 50, 60 mass%) were prepared. They were pulverized and the compacts of the resultant powders were heated to obtain the glass-ceramics. Only diopside was precipitated at x = 0 in the glass composition, whitlockite (β-TCP) and diopside were at x = 38, 50 and 60, when the compacts were sintered at 1200°C. The prepared glass-ceramics formed apatite on their surfaces in a simulated body fluid (SBF). This indicates that these glass-ceramics have a potential to show bioactivity.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalKey Engineering Materials
Volume309-311 I
Publication statusPublished - 2006


  • Apatite
  • Diopside
  • Glass-ceramics
  • Simulated body fluid (SBF)


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