Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid

Shuzo Sato; Glenn T. Gobbel; Jari Honkaniemi; Yibing Li; Takeo Kondo; Kensuke Murakami; Minako Sato; Jean Christophe Copin; Pak H. Chan

doi:10.1016/S0006-8993(96)01231-0

Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid

Shuzo Sato, Glenn T. Gobbel, Jari Honkaniemi, Yibing Li, Takeo Kondo, Kensuke Murakami, Minako Sato, Jean Christophe Copin, Pak H. Chan

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.

Original language	English
Pages (from-to)	343-347
Number of pages	5
Journal	Brain research
Volume	745
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(96)01231-0
Publication status	Published - 1997 Jan 16
Externally published	Yes

Keywords

3-Nitropropionic acid
Apoptosis
DNA fragmentation
Huntington's disease
Mitochondria

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(96)01231-0

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title = "Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid",

abstract = "The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.",

keywords = "3-Nitropropionic acid, Apoptosis, DNA fragmentation, Huntington's disease, Mitochondria",

author = "Shuzo Sato and Gobbel, {Glenn T.} and Jari Honkaniemi and Yibing Li and Takeo Kondo and Kensuke Murakami and Minako Sato and Copin, {Jean Christophe} and Chan, {Pak H.}",

note = "Funding Information: The authors would like to thank S. Chen, B. Calagui and L. Reola for their technical assistance and C. Christensen for editorial assistance. This study was supported by National Institutes of Health Grants NS 14543, NS 25372, CA 13525, and AG 08938.",

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doi = "10.1016/S0006-8993(96)01231-0",

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AU - Sato, Shuzo

AU - Gobbel, Glenn T.

AU - Honkaniemi, Jari

AU - Li, Yibing

AU - Kondo, Takeo

AU - Murakami, Kensuke

AU - Sato, Minako

AU - Copin, Jean Christophe

AU - Chan, Pak H.

N1 - Funding Information: The authors would like to thank S. Chen, B. Calagui and L. Reola for their technical assistance and C. Christensen for editorial assistance. This study was supported by National Institutes of Health Grants NS 14543, NS 25372, CA 13525, and AG 08938.

PY - 1997/1/16

Y1 - 1997/1/16

N2 - The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.

AB - The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.

KW - 3-Nitropropionic acid

KW - Apoptosis

KW - DNA fragmentation

KW - Huntington's disease

KW - Mitochondria

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JO - Molecular Brain Research

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Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid

Abstract

Keywords

ASJC Scopus subject areas

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