Apoptosis of Lymphocytes in Mice Administered Lipopolysaccharide from Leptospira interrogans

E. Isogai; H. Isogai; T. Kubota; N. Fujii; S. Hayashi; T. Indoh; S. Takagi; H. Miura; K. Kimura

doi:10.1111/j.1439-0450.1998.tb00824.x

Apoptosis of Lymphocytes in Mice Administered Lipopolysaccharide from Leptospira interrogans

E. Isogai, H. Isogai, T. Kubota, N. Fujii, S. Hayashi, T. Indoh, S. Takagi, H. Miura, K. Kimura

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We report that administration of leptospiral lipopolysaccharide (LPS) in mice results in massive surface marker changes in the lymphocytes of the spleen. It appears that many of these changes relate to the large number of cells undergoing apoptosis. It is also shown that tumor necrosis factor-alpha (TNF-α) induces similar effects and is produced in large quantities after injection of leptospiral LPS. It is likely that cytokines such as TNF-α are involved in apoptosis.

Original language	English
Pages (from-to)	529-537
Number of pages	9
Journal	Journal of Veterinary Medicine, Series B
Volume	45
Issue number	9
DOIs	https://doi.org/10.1111/j.1439-0450.1998.tb00824.x
Publication status	Published - 1998 Nov

ASJC Scopus subject areas

Medicine(all)

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10.1111/j.1439-0450.1998.tb00824.x

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abstract = "We report that administration of leptospiral lipopolysaccharide (LPS) in mice results in massive surface marker changes in the lymphocytes of the spleen. It appears that many of these changes relate to the large number of cells undergoing apoptosis. It is also shown that tumor necrosis factor-alpha (TNF-α) induces similar effects and is produced in large quantities after injection of leptospiral LPS. It is likely that cytokines such as TNF-α are involved in apoptosis.",

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AU - Kubota, T.

AU - Fujii, N.

AU - Hayashi, S.

AU - Indoh, T.

AU - Takagi, S.

AU - Miura, H.

AU - Kimura, K.

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ER -

Apoptosis of Lymphocytes in Mice Administered Lipopolysaccharide from Leptospira interrogans

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