Application of deep sequence technology in hepatology

Masashi Ninomiya, Yoshiyuki Ueno, Tooru Shimosegawa

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Deep sequencing technologies are currently cutting edge, and are opening fascinating opportunities in biomedicine, producing over 100-times more data compared to the conventional capillary sequencers based on the Sanger method. Next-generation sequencing (NGS) is now generally defined as the sequencing technology that, by employing parallel sequencing processes, producing thousands or millions of sequence reads simultaneously. Since the GS20 was released as the first NGS sequencer on the market by 454 Life Sciences, the competition in the development of the new sequencers has become intense. In this review, we describe the current deep sequencing systems and discuss the application of advanced technologies in the field of hepatology.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalHepatology Research
Issue number2
Publication statusPublished - 2014 Feb


  • Deep sequencing technology
  • Next-generation sequencing
  • Pyrosequencing
  • Sequencing-by-synthesis


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