TY - JOUR
T1 - Application of monochromatic keV X-ray source to X-ray drug delivery system
AU - Uesaka, Mitsuru
AU - Taguchi, Hiroki
AU - Mori, Azusa
AU - Yusa, Noritaka
AU - Kato, Takamitsu
AU - Okayasu, Ryuichi
PY - 2009/9/1
Y1 - 2009/9/1
N2 - X-ray Drug Delivery System (DDS) enhances accumulation of anti-cancer drug or contrast agent by surrounding it with polymer and Enhanced Penetration and Retention (EPR) effect. DDS uses advanced nano-scaled polymers that contain and deliver drug or contrast agent to cancers without side effects. Several X-ray DDSs pose high-Z atoms such as gold to absorb X-rays effectively and used as contrast agent for inspection. Moreover, they have radiation enhancement effect by emission of Auger electron and successive characteristic X-rays. The enhancement factor of gold is more than five. This could be used even for therapy. This new modality must be very important for inspection and therapy of deep cancers. We are making use of our X-band Compton scattering monochromatic keV X-ray source for the inspection. Numerical simulation on monochromatic X-ray CT for possible concentration of gold-colloid DDS considering the X-ray property from the source was done. Enough visibility was confirmed. Furthermore, in vitro experiment analyzed its toxic effect to cells by the Alkaline comet assay and fluorescent immunostaining method for single and double strand breaks of DNA. Availability of clear imaging for the inspection has been confirmed by the numerical simulation and the in-vitro evaluation of the therapy effect is under way.
AB - X-ray Drug Delivery System (DDS) enhances accumulation of anti-cancer drug or contrast agent by surrounding it with polymer and Enhanced Penetration and Retention (EPR) effect. DDS uses advanced nano-scaled polymers that contain and deliver drug or contrast agent to cancers without side effects. Several X-ray DDSs pose high-Z atoms such as gold to absorb X-rays effectively and used as contrast agent for inspection. Moreover, they have radiation enhancement effect by emission of Auger electron and successive characteristic X-rays. The enhancement factor of gold is more than five. This could be used even for therapy. This new modality must be very important for inspection and therapy of deep cancers. We are making use of our X-band Compton scattering monochromatic keV X-ray source for the inspection. Numerical simulation on monochromatic X-ray CT for possible concentration of gold-colloid DDS considering the X-ray property from the source was done. Enough visibility was confirmed. Furthermore, in vitro experiment analyzed its toxic effect to cells by the Alkaline comet assay and fluorescent immunostaining method for single and double strand breaks of DNA. Availability of clear imaging for the inspection has been confirmed by the numerical simulation and the in-vitro evaluation of the therapy effect is under way.
KW - Compton scattering
KW - Gold colloid
KW - Medical imaging
KW - Monochromatic X-ray source
KW - Toxic effect
KW - X-ray drug delivery system
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U2 - 10.1016/j.nima.2009.05.191
DO - 10.1016/j.nima.2009.05.191
M3 - Article
AN - SCOPUS:70349307197
SN - 0168-9002
VL - 608
SP - S47-S50
JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
IS - 1 SUPPL.
ER -
