TY - JOUR
T1 - Aromatic polyketide glycosides from an entomopathogenic fungus, Cordyceps indigotica
AU - Asai, Teigo
AU - Yamamoto, Takashi
AU - Chung, Yu Ming
AU - Chang, Fang Rong
AU - Wu, Yang Chang
AU - Yamashita, Kouwa
AU - Oshima, Yoshiteru
N1 - Funding Information:
This work was supported in part by Grant-in-Aid for Scientific Research (No. 23710248 and 23590582) from the Ministry of Education, Science, Sports and Culture of Japan; A-STEP (FS-stage) (No.AS221Z01739G) from Japan Science and Technology Agency (JST); the Uehara Memorial Foundation; Japan Association for Chemical Innovation.
PY - 2012/1/18
Y1 - 2012/1/18
N2 - A new aromatic polyketide glycoside, indigotide A (1), was isolated from the culture broth of the entomopathogenic fungus, Cordyceps indigotica, along with known cyclic depsipeptides, destruxins A, A 2, B, B 2 and E (3-7), and a polyketide, NG-393 (8). Repeated treatment of the C. indigotica culture broth with 5-azacytidine, a DNA methyltransferase inhibitor, led to the isolation of another new aromatic polyketide glycoside, indigotide B (2).
AB - A new aromatic polyketide glycoside, indigotide A (1), was isolated from the culture broth of the entomopathogenic fungus, Cordyceps indigotica, along with known cyclic depsipeptides, destruxins A, A 2, B, B 2 and E (3-7), and a polyketide, NG-393 (8). Repeated treatment of the C. indigotica culture broth with 5-azacytidine, a DNA methyltransferase inhibitor, led to the isolation of another new aromatic polyketide glycoside, indigotide B (2).
KW - DNA methyltransferase inhibitor
KW - Entomopathogenic fungi
KW - Epigenetics
KW - Polyketides
KW - Secondary metabolites
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U2 - 10.1016/j.tetlet.2011.10.013
DO - 10.1016/j.tetlet.2011.10.013
M3 - Article
AN - SCOPUS:83555161527
SN - 0040-4039
VL - 53
SP - 277
EP - 280
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 3
ER -