ASK1 Signalosome: A Signaling Complex Essential for Cellular Stress Responses

Kohsuke Takeda, Takuya Noguchi, Hidenori Ichijo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein (MAP) kinase kinase kinase that activates the JNK and p38 MAP kinase cascades. ASK1 has a broad range of biological activities including cell differentiation and stress-induced apoptosis. Recently, we have shown that endogenous ASK1 constitutively forms a high molecular mass complex, which we designate “ASK1 signalosome”. Here we introduce this novel signaling complex as a key regulator of cell fate in response to oxidative stress.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
Journaljournal of oral biosciences
Issue number1
Publication statusPublished - 2005 Jan 1
Externally publishedYes


  • ASK1
  • MAP kinase
  • reactive oxygen species(ROS)
  • signalosome
  • stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Dentistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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