ASK1 Signalosome: A Signaling Complex Essential for Cellular Stress Responses

Kohsuke Takeda; Takuya Noguchi; Hidenori Ichijo

doi:10.2330/joralbiosci.48.7

ASK1 Signalosome: A Signaling Complex Essential for Cellular Stress Responses

Kohsuke Takeda, Takuya Noguchi, Hidenori Ichijo

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein (MAP) kinase kinase kinase that activates the JNK and p38 MAP kinase cascades. ASK1 has a broad range of biological activities including cell differentiation and stress-induced apoptosis. Recently, we have shown that endogenous ASK1 constitutively forms a high molecular mass complex, which we designate “ASK1 signalosome”. Here we introduce this novel signaling complex as a key regulator of cell fate in response to oxidative stress.

Original language	English
Pages (from-to)	7-11
Number of pages	5
Journal	journal of oral biosciences
Volume	48
Issue number	1
DOIs	https://doi.org/10.2330/joralbiosci.48.7
Publication status	Published - 2005 Jan 1
Externally published	Yes

Keywords

ASK1
MAP kinase
reactive oxygen species(ROS)
signalosome
stress

ASJC Scopus subject areas

Medicine (miscellaneous)
Dentistry(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.2330/joralbiosci.48.7

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abstract = "Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein (MAP) kinase kinase kinase that activates the JNK and p38 MAP kinase cascades. ASK1 has a broad range of biological activities including cell differentiation and stress-induced apoptosis. Recently, we have shown that endogenous ASK1 constitutively forms a high molecular mass complex, which we designate “ASK1 signalosome”. Here we introduce this novel signaling complex as a key regulator of cell fate in response to oxidative stress.",

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author = "Kohsuke Takeda and Takuya Noguchi and Hidenori Ichijo",

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AU - Takeda, Kohsuke

AU - Noguchi, Takuya

AU - Ichijo, Hidenori

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein (MAP) kinase kinase kinase that activates the JNK and p38 MAP kinase cascades. ASK1 has a broad range of biological activities including cell differentiation and stress-induced apoptosis. Recently, we have shown that endogenous ASK1 constitutively forms a high molecular mass complex, which we designate “ASK1 signalosome”. Here we introduce this novel signaling complex as a key regulator of cell fate in response to oxidative stress.

AB - Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein (MAP) kinase kinase kinase that activates the JNK and p38 MAP kinase cascades. ASK1 has a broad range of biological activities including cell differentiation and stress-induced apoptosis. Recently, we have shown that endogenous ASK1 constitutively forms a high molecular mass complex, which we designate “ASK1 signalosome”. Here we introduce this novel signaling complex as a key regulator of cell fate in response to oxidative stress.

KW - ASK1

KW - MAP kinase

KW - reactive oxygen species(ROS)

KW - signalosome

KW - stress

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ER -

ASK1 Signalosome: A Signaling Complex Essential for Cellular Stress Responses

Abstract

Keywords

ASJC Scopus subject areas

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