Assembly of Ag@Au nanoparticles using complementary stranded DNA molecules and their detection using UV-Vis and Raman spectroscopic techniques

Derrick Mott, Nguyen T.B. Thuy, Yoshiya Aoki, Shinya Maenosono

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Silver nanoparticles coated by a layer of gold (Ag@Au) have received much attention because of their potential application as ultra sensitive probes for the detection of biologically important molecules such as DNA, proteins, amino acids and many others. However, the ability to control the size, shape, and monodispersity of the Ag@Au structure has met with limited success. In our own research we have addressed this challenge by creating an aqueous wet chemical synthesis technique towards size and shape controllable Ag@Au nanoparticles. These materials are highly interesting because of the tunable silver core size, and the tunable gold shell thickness, opening many avenues to the modification of the particle properties in terms of biomolecular sensing. The resulting nanoparticle probes were functionalized with two complementary stranded DNA oligonucleotides. When combined, the complementary strands hybridized, causing the Ag@Au nanoparticles to assemble into large nano-structures. The presence of the oligonucleotide was confirmed through a series of techniques including UV-Vis and Raman spectroscopy, as well as TEM, XPS, DLS, and many others. The results reflect the role that the nanoparticle physical properties play in the detection of the bio-molecules, as well as elucidate the characteristics of the bio-molecule/nanoparticle interaction.

Original languageEnglish
Title of host publicationIntegrated Miniaturized Materials - From Self-Assembly to Device Integration
Number of pages6
Publication statusPublished - 2010 Dec 1
Externally publishedYes
Event2010 MRS Spring Meeting - San Francisco, CA, United States
Duration: 2010 Apr 52010 Apr 9

Publication series

NameMaterials Research Society Symposium Proceedings
ISSN (Print)0272-9172


Other2010 MRS Spring Meeting
Country/TerritoryUnited States
CitySan Francisco, CA

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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