Assessment of biological effect of minimal acupuncture using causal coherence function between blood pressure and heart rate

Norihiro Sugita, Takashi Seki, Makoto Yoshizawa, Makoto Abe, Akira Tanaka, Ken Ichi Abe, Tomoyuki Yambe, Shin Ichi Nitta

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


To assess the effect of acupuncture on the human, 17 healthy volunteers participated in a double-blind randomized crossover clinical trial using real-needle and no-needle seals. In this study, by using systolic blood pressure variability (SBP) and heart rate variability (HR), not only coherence function (K2) between SBP and HR but also two causal coherence functions: K2SBP→HR from SBP to HR and K2 HR→SBP from HR to SBP were introduced to divide causal linearity of the cardiovascular system regarded as a closed-loop system. K2 represents total linearity of the system. K2SBP→HR and K2 HR→SBP correspond to the baroreflex system and the mechanical hemodynamics, respectively. The results showed that K 2SBp→HR over the low frequency band (0.04-0.15Hz) underwent a lot of change in real-needle acupuncture but did not in no-needle acupuncture. And there was difference in K2HR→SBP over the high frequency band (0.15-0.45Hz) immediately after the stimulation of acupuncture. These results have never been obtained from conventional methods dealing with a cardiovascular system as an open-loop system.

Original languageEnglish
Title of host publication2006 SICE-ICASE International Joint Conference
Number of pages4
Publication statusPublished - 2006
Event2006 SICE-ICASE International Joint Conference - Busan, Korea, Republic of
Duration: 2006 Oct 182006 Oct 21

Publication series

Name2006 SICE-ICASE International Joint Conference


Conference2006 SICE-ICASE International Joint Conference
Country/TerritoryKorea, Republic of


  • Acupuncture
  • Blood pressure
  • Causal coherence function
  • Heart rate


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