Assessment of cancer susceptibility in humans by use of genetic polymorphisms in carcinogen metabolism

Shuntaro Ikawa; Fumiyuki Uematsu; Ko Ichi Watanabe; Teiko Kimpara; Motonobu Osada; Anwar Hossain; Ikuko Sagami; Hideaki Kikuchi; Minro Watanabe

doi:10.1097/00008571-199512001-00019

Assessment of cancer susceptibility in humans by use of genetic polymorphisms in carcinogen metabolism

Shuntaro Ikawa, Fumiyuki Uematsu, Ko Ichi Watanabe, Teiko Kimpara, Motonobu Osada, Anwar Hossain, Ikuko Sagami, Hideaki Kikuchi, Minro Watanabe

IDAC - Division of Aging Science

Tohoku University

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Prevention is an important and effective measure for reducing death caused by cancer. Thus information on individual susceptibility to cancer is valuable in suggesting high risk individuals to avoid intake of carcinogenic substances and receive frequent physical screening. To this end, polymorphisms found within cytochrome P450 (CYP) genes implicated in the metabolism of procarcinogens are expected to be good genetic targets in assessing human cancer susceptibility. We have found polymorphisms in the CYP2E1 and CYP1A1 genes associated with lung cancer susceptibility, though there were some discrepancies from observations made by other investigators. Discrepancies among investigators from different regions, however, are very common in these pharmacogenetic studies. We present an explanation for these discrepancies, difficulties associated with prediction of relative risk of individuals, and future directions.

Original language	English
Pages (from-to)	S154-S160
Journal	Pharmacogenetics
Volume	5
DOIs	https://doi.org/10.1097/00008571-199512001-00019
Publication status	Published - 1995 Dec

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10.1097/00008571-199512001-00019

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abstract = "Prevention is an important and effective measure for reducing death caused by cancer. Thus information on individual susceptibility to cancer is valuable in suggesting high risk individuals to avoid intake of carcinogenic substances and receive frequent physical screening. To this end, polymorphisms found within cytochrome P450 (CYP) genes implicated in the metabolism of procarcinogens are expected to be good genetic targets in assessing human cancer susceptibility. We have found polymorphisms in the CYP2E1 and CYP1A1 genes associated with lung cancer susceptibility, though there were some discrepancies from observations made by other investigators. Discrepancies among investigators from different regions, however, are very common in these pharmacogenetic studies. We present an explanation for these discrepancies, difficulties associated with prediction of relative risk of individuals, and future directions.",

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T1 - Assessment of cancer susceptibility in humans by use of genetic polymorphisms in carcinogen metabolism

AU - Ikawa, Shuntaro

AU - Uematsu, Fumiyuki

AU - Watanabe, Ko Ichi

AU - Kimpara, Teiko

AU - Osada, Motonobu

AU - Hossain, Anwar

AU - Sagami, Ikuko

AU - Kikuchi, Hideaki

AU - Watanabe, Minro

PY - 1995/12

Y1 - 1995/12

N2 - Prevention is an important and effective measure for reducing death caused by cancer. Thus information on individual susceptibility to cancer is valuable in suggesting high risk individuals to avoid intake of carcinogenic substances and receive frequent physical screening. To this end, polymorphisms found within cytochrome P450 (CYP) genes implicated in the metabolism of procarcinogens are expected to be good genetic targets in assessing human cancer susceptibility. We have found polymorphisms in the CYP2E1 and CYP1A1 genes associated with lung cancer susceptibility, though there were some discrepancies from observations made by other investigators. Discrepancies among investigators from different regions, however, are very common in these pharmacogenetic studies. We present an explanation for these discrepancies, difficulties associated with prediction of relative risk of individuals, and future directions.

AB - Prevention is an important and effective measure for reducing death caused by cancer. Thus information on individual susceptibility to cancer is valuable in suggesting high risk individuals to avoid intake of carcinogenic substances and receive frequent physical screening. To this end, polymorphisms found within cytochrome P450 (CYP) genes implicated in the metabolism of procarcinogens are expected to be good genetic targets in assessing human cancer susceptibility. We have found polymorphisms in the CYP2E1 and CYP1A1 genes associated with lung cancer susceptibility, though there were some discrepancies from observations made by other investigators. Discrepancies among investigators from different regions, however, are very common in these pharmacogenetic studies. We present an explanation for these discrepancies, difficulties associated with prediction of relative risk of individuals, and future directions.

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Assessment of cancer susceptibility in humans by use of genetic polymorphisms in carcinogen metabolism

Abstract

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