TY - JOUR
T1 - Association between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses among Children
T2 - A Prospective Cohort Study in the Philippines
AU - Furuse, Yuki
AU - Tamaki, Raita
AU - Okamoto, Michiko
AU - Saito-Obata, Mariko
AU - Suzuki, Akira
AU - Saito, Mayuko
AU - Imamura, Tadatsugu
AU - Khandaker, Irona
AU - Dapat, Isolde
AU - Ueno, Fumihiko
AU - Alday, Portia Parian
AU - Tan, Alvin Gue
AU - Inobaya, Marianette Tawat
AU - Segubre-Mercado, Edelwisa
AU - Tallo, Veronica
AU - Lupisan, Socorro
AU - Oshitani, Hitoshi
N1 - Funding Information:
Financial support. This work was funded by Science and Technology Research Partnership for Sustainable Development (Grant Number JP16jm0110001) from the Japan International Cooperation Agency and the Japan Agency for Medical Research and Development (AMED), the Japan Initiative for Global Research Network on Infectious Diseases (Grant Number JP16fm0108013) from the Ministry of Education, Culture, Sport, Science & Technology in Japan (MEXT) and AMED, KAKENHI (Grant Number JP16H02642) from Japan Society for the Promotion of Science (JSPS), Creative Interdisciplinary Research Program funding from Tohoku University, and the Leading Initiative for Excellent Young Researchers from the MEXT and JSPS. Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.
Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2019/1/7
Y1 - 2019/1/7
N2 - Background Acute respiratory infection (ARI) is of great concern in public health. It remains unclear whether viral infections can affect the host's susceptibility to subsequent ARIs. Methods A prospective cohort study on ARIs of children below 5 years old was conducted in the Philippines from 2014 to 2016. The respiratory symptoms were recorded daily, and nasopharyngeal swabs were collected at both household and health facilities. The specimens were tested for respiratory viruses. We then determined whether viral etiology was associated with the severity of the present ARI and whether previous viral infections was associated with subsequent ARIs. Results A total of 3851 children and 16337 ARI episodes were enrolled and recorded, respectively. Samples were collected from 24% of all ARI episodes; collection rate at the healthcare facilities was 95%. Enterovirus D68, rhinovirus species C, and respiratory syncytial virus were significantly associated with severe ARIs. The risk for subsequent ARIs was significantly enhanced after infections with adenovirus, influenza A virus, parainfluenza virus type 4, and rhinovirus species C. Conclusions This study revealed that viral etiology plays a significant role in the severity of the present ARI and that viral infection affects the host's susceptibility to subsequent ARIs.
AB - Background Acute respiratory infection (ARI) is of great concern in public health. It remains unclear whether viral infections can affect the host's susceptibility to subsequent ARIs. Methods A prospective cohort study on ARIs of children below 5 years old was conducted in the Philippines from 2014 to 2016. The respiratory symptoms were recorded daily, and nasopharyngeal swabs were collected at both household and health facilities. The specimens were tested for respiratory viruses. We then determined whether viral etiology was associated with the severity of the present ARI and whether previous viral infections was associated with subsequent ARIs. Results A total of 3851 children and 16337 ARI episodes were enrolled and recorded, respectively. Samples were collected from 24% of all ARI episodes; collection rate at the healthcare facilities was 95%. Enterovirus D68, rhinovirus species C, and respiratory syncytial virus were significantly associated with severe ARIs. The risk for subsequent ARIs was significantly enhanced after infections with adenovirus, influenza A virus, parainfluenza virus type 4, and rhinovirus species C. Conclusions This study revealed that viral etiology plays a significant role in the severity of the present ARI and that viral infection affects the host's susceptibility to subsequent ARIs.
KW - Philippines
KW - acute respiratory infection
KW - prospective cohort study
KW - risk factor
KW - viral infection
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U2 - 10.1093/infdis/jiy515
DO - 10.1093/infdis/jiy515
M3 - Article
C2 - 30189092
AN - SCOPUS:85059237178
SN - 0022-1899
VL - 219
SP - 197
EP - 205
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -
