TY - JOUR
T1 - Association between radiation dose to the heart and myocardial fatty acid metabolic impairment due to chemoradiation-therapy
T2 - Prospective study using I-123 BMIPP SPECT/CT
AU - Takanami, Kentaro
AU - Arai, Akira
AU - Umezawa, Rei
AU - Takeuchi, Takashi
AU - Kadoya, Noriyuki
AU - Taki, Yasuyuki
AU - Jingu, Keiichi
AU - Takase, Kei
N1 - Funding Information:
Financial support was provided by Japan Society for the Promotion of Science (JSPS) – KAKENHI Grant Number 24791267 .
Publisher Copyright:
© 2016 Elsevier Ireland Ltd. All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Purpose To investigate long term changes in myocardial fatty acid metabolic impairment caused by chemoradiation-therapy (CRT). Materials and methods We investigated 12 esophageal cancer patients who underwent SPECT/CT using I-123-labeled fatty acid analog (BMIPP) at pre-CRT, pre-boost irradiation, 3-month post-CRT, and 1-year post-CRT. The myocardial uptake was measured using the defect score and the total percentage of uptake (%uptake), which were defined as the sum of the visual scores and that of %uptake in each of 17 segments in the left ventricle (LV), respectively. The correlations between radiation dose to the heart (mean dose, V20, V40, and V60 of the LV and the whole heart (WH)) and the change of myocardial BMIPP uptake from pre-CRT (Δmyocardial BMIPP uptake) were assessed. Results At pre-boost, Δmyocardial BMIPP uptake was significantly correlated with LV-V40 and WH-V60. At 3-month post-CRT, Δmyocardial BMIPP uptake was significantly correlated with LV-V40, WH-V40, and WH-V60. However, there were no statistically significant correlations at 1-year post-CRT. Neither mean dose nor V20 of the LV/WH was significantly correlated with Δmyocardial BMIPP uptake at any time. Conclusions In the long term after CRT, myocardial metabolism might be affected by factors other than the radiation dose to the heart.
AB - Purpose To investigate long term changes in myocardial fatty acid metabolic impairment caused by chemoradiation-therapy (CRT). Materials and methods We investigated 12 esophageal cancer patients who underwent SPECT/CT using I-123-labeled fatty acid analog (BMIPP) at pre-CRT, pre-boost irradiation, 3-month post-CRT, and 1-year post-CRT. The myocardial uptake was measured using the defect score and the total percentage of uptake (%uptake), which were defined as the sum of the visual scores and that of %uptake in each of 17 segments in the left ventricle (LV), respectively. The correlations between radiation dose to the heart (mean dose, V20, V40, and V60 of the LV and the whole heart (WH)) and the change of myocardial BMIPP uptake from pre-CRT (Δmyocardial BMIPP uptake) were assessed. Results At pre-boost, Δmyocardial BMIPP uptake was significantly correlated with LV-V40 and WH-V60. At 3-month post-CRT, Δmyocardial BMIPP uptake was significantly correlated with LV-V40, WH-V40, and WH-V60. However, there were no statistically significant correlations at 1-year post-CRT. Neither mean dose nor V20 of the LV/WH was significantly correlated with Δmyocardial BMIPP uptake at any time. Conclusions In the long term after CRT, myocardial metabolism might be affected by factors other than the radiation dose to the heart.
KW - Esophageal cancer
KW - Fatty acid metabolism
KW - I-123 BMIPP
KW - Radiation-induced heart disease
KW - Radiotherapy
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U2 - 10.1016/j.radonc.2016.01.024
DO - 10.1016/j.radonc.2016.01.024
M3 - Article
C2 - 26873792
AN - SCOPUS:84957916406
SN - 0167-8140
VL - 119
SP - 77
EP - 83
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 1
ER -
