Association between septal deviation and sinonasal papilloma

Kazuhiro Nomura, Takenori Ogawa, Mitsuru Sugawara, Yohei Honkura, Hidetoshi Oshima, Kazuya Arakawa, Takeshi Oshima, Yukio Katori

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Sinonasal papilloma is a common benign epithelial tumor of the sinonasal tract and accounts for 0.5% to 4% of all nasal tumors. The etiology of sinonasal papilloma remains unclear, although human papilloma virus has been proposed as a major risk factor. Other etiological factors, such as anatomical variations of the nasal cavity, may be related to the pathogenesis of sinonasal papilloma, because deviated nasal septum is seen in patients with chronic rhinosinusitis. We, therefore, investigated the involvement of deviated nasal septum in the development of sinonasal papilloma. Preoperative computed tomography or magnetic resonance imaging findings of 83 patients with sinonasal papilloma were evaluated retrospectively. The side of papilloma and the direction of septal deviation showed a significant correlation. Septum deviated to the intact side in 51 of 83 patients (61.4%) and to the affected side in 18 of 83 patients (21.7%). Straight or S-shaped septum was observed in 14 of 83 patients (16.9%). Even after excluding 27 patients who underwent revision surgery and 15 patients in whom the papilloma touched the concave portion of the nasal septum, the concave side of septal deviation was associated with the development of sinonasal papilloma (p = 0.040). The high incidence of sinonasal papilloma in the concave side may reflect the consequences of the traumatic effects caused by wall shear stress of the high-velocity airflow and the increased chance of inhaling viruses and pollutants. The present study supports the causative role of human papilloma virus and toxic chemicals in the occurrence of sinonasal papilloma.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalTohoku Journal of Experimental Medicine
Issue number4
Publication statusPublished - 2013


  • Airflow
  • Chronic rhinosinusitis
  • Human papilloma virus
  • Inverted papilloma
  • Septal deviation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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