TY - JOUR
T1 - Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume
T2 - a cross-sectional study
AU - Sato, Shuichi
AU - Imaeda, Takao
AU - Mugikura, Shunji
AU - Mori, Naoko
AU - Takanashi, Masaki
AU - Hayakawa, Kazumi
AU - Saito, Tomo
AU - Taira, Makiko
AU - Narita, Akira
AU - Kogure, Mana
AU - Chiba, Ippei
AU - Hatanaka, Rieko
AU - Nakaya, Kumi
AU - Kanno, Ikumi
AU - Ishiwata, Ryosuke
AU - Nakamura, Tomohiro
AU - Motoike, Ikuko N.
AU - Nakaya, Naoki
AU - Koshiba, Seizo
AU - Kinoshita, Kengo
AU - Kuriyama, Shinichi
AU - Ogishima, Soichi
AU - Nagami, Fuji
AU - Fuse, Nobuo
AU - Hozawa, Atsushi
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Few population-based studies including younger adults have examined the potential of olfactory function tests to capture the degree of atrophy in memory-associated brain regions, which cannot be adequately explained by cognitive function tests screening for cognitive impairment. This population-based study investigated associations between high-resolution olfactory test data with few odours and grey matter volumes (GMVs) of the left and right hippocampi, amygdala, parahippocampi, and olfactory cortex, while accounting for differences in cognitive decline, in 1444 participants (aged 31–91 years). Regression analyses included intracranial volume (ICV)-normalised GMVs of eight memory-related regions as objective variables and age, sex, education duration, smoking history, olfaction test score, and the Montreal Cognitive Assessment-Japanese version (MoCA-J) score as explanatory variables. Significant relationships were found between olfactory test scores and ICV-normalised GMVs of the left and right hippocampi and left amygdala (p = 0.020, 0.024, and 0.028, respectively), adjusting for the MoCA-J score. The olfactory test score was significantly related to the right amygdalar GMV (p = 0.020) in older adults (age ≥ 65 years). These associations remained significant after applying Benjamini–Hochberg multiple testing correction (false discovery rate < 0.1). Therefore, olfactory and cognitive function tests may efficiently capture the degree of atrophy in the hippocampi and amygdala, especially in older adults.
AB - Few population-based studies including younger adults have examined the potential of olfactory function tests to capture the degree of atrophy in memory-associated brain regions, which cannot be adequately explained by cognitive function tests screening for cognitive impairment. This population-based study investigated associations between high-resolution olfactory test data with few odours and grey matter volumes (GMVs) of the left and right hippocampi, amygdala, parahippocampi, and olfactory cortex, while accounting for differences in cognitive decline, in 1444 participants (aged 31–91 years). Regression analyses included intracranial volume (ICV)-normalised GMVs of eight memory-related regions as objective variables and age, sex, education duration, smoking history, olfaction test score, and the Montreal Cognitive Assessment-Japanese version (MoCA-J) score as explanatory variables. Significant relationships were found between olfactory test scores and ICV-normalised GMVs of the left and right hippocampi and left amygdala (p = 0.020, 0.024, and 0.028, respectively), adjusting for the MoCA-J score. The olfactory test score was significantly related to the right amygdalar GMV (p = 0.020) in older adults (age ≥ 65 years). These associations remained significant after applying Benjamini–Hochberg multiple testing correction (false discovery rate < 0.1). Therefore, olfactory and cognitive function tests may efficiently capture the degree of atrophy in the hippocampi and amygdala, especially in older adults.
KW - Brain atrophy
KW - Cognitive function
KW - Cross-sectional studies
KW - Grey matter volume
KW - Multiple regression
KW - Olfactory function
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U2 - 10.1038/s41598-024-69726-4
DO - 10.1038/s41598-024-69726-4
M3 - Article
C2 - 39160183
AN - SCOPUS:85201573940
SN - 2045-2322
VL - 14
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 19138
ER -