Association of post-reperfusion syndrome and ischemia-reperfusion injury with acute kidney injury after liver transplantation

Kazuaki Tokodai, Claudia Lannsjö, Felicia Kjaernet, Antonio Romano, Anna Januszkiewicz, Bo Göran Ericzon, Greg Nowak

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Background: Acute kidney injury (AKI) is frequently observed after orthotopic liver transplantation (OLT) even in patients with previously normal renal function. In this study, we investigated the impact of factors such graft steatosis, post-reperfusion syndrome (PRS), and hepatic ischemia reperfusion injury (HIRI) on the development of AKI after OLT in adult patients. Methods: We retrospectively examined consecutive adult patients who underwent OLT at our institution between July 2011 and June 2017. AKI was diagnosed based on the criteria proposed by the International Kidney Disease Improving Global Outcomes (KDIGO) workgroup. Peak aspartate aminotransferase (AST) level within 72 hours after OLT was used as a surrogate marker for HIRI. Graft steatosis was diagnosed by histopathological examination using specimens biopsied intraoperatively at the end of transplantation procedure and categorized as <10%, 10%-20%, 20%-30%, and ≥30% of hepatic steatosis. Results: Out of 386 patients, 141 (37%) developed AKI (KDIGO stage 1:71 patients; stage 2:29 patients; stage 3:41 patients). Multivariable logistic regression analysis revealed that cold ischemic time (P =.012) and HIRI (P =.007) were independent risk factors for post-OLT AKI. Multivariable analysis also revealed that graft steatosis was associated with HIRI but not directly with AKI. PRS was not associated with HIRI or AKI in the multivariable analyses. Conclusion: Our results indicate that greater severity of liver graft injury during transplantation negatively affects renal function after OLT. As expected, the severity of liver graft steatosis contributes to accelerated liver injury occurring during the transplantation procedure.

Original languageEnglish
Pages (from-to)742-750
Number of pages9
JournalActa Anaesthesiologica Scandinavica
Issue number6
Publication statusPublished - 2020 Jul 1


Dive into the research topics of 'Association of post-reperfusion syndrome and ischemia-reperfusion injury with acute kidney injury after liver transplantation'. Together they form a unique fingerprint.

Cite this