TY - JOUR
T1 - Association of (pro)renin receptor gene polymorphism with blood pressure in Japanese men
T2 - The Ohasama study
AU - Hirose, Takuo
AU - Hashimoto, Masahiro
AU - Totsune, Kazuhito
AU - Metoki, Hirohito
AU - Asayama, Kei
AU - Kikuya, Masahiro
AU - Sugimoto, Ken
AU - Katsuya, Tomohiro
AU - Ohkubo, Takayoshi
AU - Hashimoto, Junichiro
AU - Rakugi, Hiromi
AU - Takahashi, Kazuhiro
AU - Imai, Yutaka
N1 - Funding Information:
Supplementary material is linked to the online version of the paper at http:// www.nature.com/ajh acknowledgments: We are grateful to the residents in Ohasama Town, all related investigators and study staff, and staff members of the Ohasama Town Government, Ohasama hospital and Iwate Prefectural Stroke registry for their valuable support on this project.This study was performed in part to use an equipment in Biomedical research core of Tohoku University Graduate School of Medicine.This study was supported in part by Grants for Scientific research (15790293, 16590433, 17790381, 18390192, 18590587, 19590929, and 19790423) from the Ministry of Education, culture, Sports, Science, and Technology, Japan; Grant-in-aid (h17-Kenkou-007, h18-Junkankitou[Seishuu]-Ippan-012, and h20-Junkankitou[Seishuu]-Ippan-009, 013) from the Ministry of health, Labor and Welfare, health and Labor Sciences research Grants, Japan; Grant-in-aid for Japan Society for the Promotion of Science (JSPS) fellows (16.54041, 18.54042, 19.7152, 20.7198, 20.7477, and 20.54043); health Science research Grants and Medical Technology Evaluation research Grants from the Ministry of health, Labor andWelfare, Japan; Japan atherosclerosis Prevention Fund; Uehara Memorial Foundation; Takeda Medical research Foundation; National cardiovascular research Grants; and Biomedical Innovation Grants.
PY - 2009/3
Y1 - 2009/3
N2 - Background: Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system (RAS), is associated with blood pressure regulation in animals. However, there is no information on (P)RR in humans. We investigated the association of (P)RR gene polymorphisms with blood pressure in a Japanese population. Methods: Subjects (n = 1,112) were recruited from participants in the Ohasama study, a Japanese cohort study. For the association study, we selected three polymorphisms: -782A>G (rs2968915), intervening sequence (IVS)5+169C>T (rs5918007), and +1513A>G (rs6609080). Because the (P)RR gene is on the X chromosome, men (n = 357) and women (n = 755) were analyzed separately. Results: In men, 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP) values, daytime SBP and DBP values, and nighttime SBP and DBP values were significantly higher in IVS5+169T allele carriers than C allele carriers. Multiple regression analysis showed that IVS5+169C>T was significantly and independently related to ambulatory blood pressure (ABP). IVS5+169C>T was not associated with casual blood pressure (CBP) in men. In women, there were no significant differences in blood pressure values among the three genotypes of IVS5+169C>T. This polymorphism had no significant association with any other clinical characteristic. -782A>G was weakly associated with ABP in men. +1513A>G was not associated with blood pressure values in either men or women. Conclusions: We demonstrated for the first time that polymorphism of the (P)RR gene IVS5+169C>T is associated with ABP in Japanese men. This association suggests that (P)RR has a role in blood pressure regulation.
AB - Background: Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system (RAS), is associated with blood pressure regulation in animals. However, there is no information on (P)RR in humans. We investigated the association of (P)RR gene polymorphisms with blood pressure in a Japanese population. Methods: Subjects (n = 1,112) were recruited from participants in the Ohasama study, a Japanese cohort study. For the association study, we selected three polymorphisms: -782A>G (rs2968915), intervening sequence (IVS)5+169C>T (rs5918007), and +1513A>G (rs6609080). Because the (P)RR gene is on the X chromosome, men (n = 357) and women (n = 755) were analyzed separately. Results: In men, 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP) values, daytime SBP and DBP values, and nighttime SBP and DBP values were significantly higher in IVS5+169T allele carriers than C allele carriers. Multiple regression analysis showed that IVS5+169C>T was significantly and independently related to ambulatory blood pressure (ABP). IVS5+169C>T was not associated with casual blood pressure (CBP) in men. In women, there were no significant differences in blood pressure values among the three genotypes of IVS5+169C>T. This polymorphism had no significant association with any other clinical characteristic. -782A>G was weakly associated with ABP in men. +1513A>G was not associated with blood pressure values in either men or women. Conclusions: We demonstrated for the first time that polymorphism of the (P)RR gene IVS5+169C>T is associated with ABP in Japanese men. This association suggests that (P)RR has a role in blood pressure regulation.
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U2 - 10.1038/ajh.2008.357
DO - 10.1038/ajh.2008.357
M3 - Article
C2 - 19131936
AN - SCOPUS:60649085140
SN - 0895-7061
VL - 22
SP - 294
EP - 299
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 3
ER -