TY - JOUR
T1 - Association of serum apolipoprotein B48 level with the presence of carotid plaque in type 2 diabetes mellitus
AU - Tanimura, Kyoko
AU - Nakajima, Yasushi
AU - Nagao, Mototugu
AU - Ishizaki, Akira
AU - Kano, Toshiko
AU - Harada, Taro
AU - Okajima, Fumitaka
AU - Sudo, Mariko
AU - Tamura, Hideki
AU - Ishii, Shinya
AU - Sugihara, Hitoshi
AU - Yamashita, Shizuya
AU - Asai, Akira
AU - Oikawa, Shinichi
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/9
Y1 - 2008/9
N2 - Aims: The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients. Method: Forty type 2 diabetic patients (21 males and 19 females, 52.8 ± 11.8 years old; mean ± S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay. Results: Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5 ± 3.8 vs. 4.1 ± 1.9 μg/ml, p = 0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p = 0.04) and triglyceride (OR 1.14; 95% CI, 1.02-1.32, p = 0.04) levels. In normal LDL-cholesterol (<140 mg/dl) subjects, the presence of carotid plaque was associated with fasting apoB48 level (OR 2.16; 95% CI, 1.22-5.32, p = 0.04), but not associated with fasting triglyceride level (OR 1.11; 95% CI, 0.99-1.30, p = 0.13). Conclusions: Serum apoB48 level was strongly associated with the presence of carotid plaque in type 2 diabetic patients.
AB - Aims: The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients. Method: Forty type 2 diabetic patients (21 males and 19 females, 52.8 ± 11.8 years old; mean ± S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay. Results: Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5 ± 3.8 vs. 4.1 ± 1.9 μg/ml, p = 0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p = 0.04) and triglyceride (OR 1.14; 95% CI, 1.02-1.32, p = 0.04) levels. In normal LDL-cholesterol (<140 mg/dl) subjects, the presence of carotid plaque was associated with fasting apoB48 level (OR 2.16; 95% CI, 1.22-5.32, p = 0.04), but not associated with fasting triglyceride level (OR 1.11; 95% CI, 0.99-1.30, p = 0.13). Conclusions: Serum apoB48 level was strongly associated with the presence of carotid plaque in type 2 diabetic patients.
KW - Apolipoprotein B48
KW - Carotid plaque
KW - Diurnal change
KW - ELISA
KW - Type 2 diabetes mellitus
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U2 - 10.1016/j.diabres.2008.04.028
DO - 10.1016/j.diabres.2008.04.028
M3 - Article
C2 - 18632179
AN - SCOPUS:48949084729
SN - 0168-8227
VL - 81
SP - 338
EP - 344
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 3
ER -
