TY - JOUR
T1 - Association of swine leukocyte antigen class II haplotypes and immune-related traits in a swine line selected for resistance to mycoplasmal pneumonia
AU - Ando, Asako
AU - Shigenari, Atsuko
AU - Kojima-Shibata, Chihiro
AU - Nakajoh, Mitsuru
AU - Suzuki, Keiichi
AU - Kitagawa, Hitoshi
AU - Shiina, Takashi
AU - Inoko, Hidetoshi
AU - Uenishi, Hirohide
N1 - Funding Information:
This study was supported by grants from the Animal Genome Research Project (2101) and the Project of Animal Genomics for Innovative Breeding Technology (AGB1002) of the Ministry of Agriculture, Forestry and Fisheries of Japan . We thank Dr. Eisaku Suzuki (a former researcher at Miyagi Livestock Experimental Station) and Ms. Hisako Kawata (Education and Research Support Center in the Tokai University School of Medicine) for providing us with samples for Miyagino L2 pigs and technical assistance, respectively.
Publisher Copyright:
© 2016 Elsevier Ltd
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - By selective breeding for five generations, a Landrace line has been recently established to improve resistance to mycoplasmal pneumonia of swine (MPS), daily gain (DG), back fat thickness (BF), and plasma cortisol concentrations (COR). To clarify the involvement of swine leukocyte antigen (SLA) polymorphisms in the selection process, we investigated possible associations of 11 SLA-class II haplotypes with selected traits or immune parameters. Pigs with the low-resolution SLA haplotype Lr-0.23 or Lr-0.13, which increased in frequency with the passage of generations, had less severe pathological lesions of MPS, increased leukocyte phagocytic activity, and higher white blood cell counts. In contrast, Lr-0.12 and Lr-0.2, which decreased in subsequent generations, were weakly associated with more severe pathological lesions of MPS. Therefore, in the studied Landrace line, the Lr-0.23 and Lr-0.13 haplotypes are potentially useful genetic markers for selecting and breeding animals with less severe pathological lesions of MPS.
AB - By selective breeding for five generations, a Landrace line has been recently established to improve resistance to mycoplasmal pneumonia of swine (MPS), daily gain (DG), back fat thickness (BF), and plasma cortisol concentrations (COR). To clarify the involvement of swine leukocyte antigen (SLA) polymorphisms in the selection process, we investigated possible associations of 11 SLA-class II haplotypes with selected traits or immune parameters. Pigs with the low-resolution SLA haplotype Lr-0.23 or Lr-0.13, which increased in frequency with the passage of generations, had less severe pathological lesions of MPS, increased leukocyte phagocytic activity, and higher white blood cell counts. In contrast, Lr-0.12 and Lr-0.2, which decreased in subsequent generations, were weakly associated with more severe pathological lesions of MPS. Therefore, in the studied Landrace line, the Lr-0.23 and Lr-0.13 haplotypes are potentially useful genetic markers for selecting and breeding animals with less severe pathological lesions of MPS.
KW - Disease association
KW - Genotype
KW - Haplotype
KW - Mycoplasmal pneumonia
KW - Swine leukocyte antigen
UR - http://www.scopus.com/inward/record.url?scp=84979788571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84979788571&partnerID=8YFLogxK
U2 - 10.1016/j.cimid.2016.07.004
DO - 10.1016/j.cimid.2016.07.004
M3 - Article
C2 - 27638117
AN - SCOPUS:84979788571
SN - 0147-9571
VL - 48
SP - 33
EP - 40
JO - Comparative Immunology, Microbiology and Infectious Diseases
JF - Comparative Immunology, Microbiology and Infectious Diseases
ER -
