TY - JOUR
T1 - Association study of long non-coding RNA HOTAIR rs920778 polymorphism with the risk of cancer in an elderly Japanese population
AU - Minn, Aye Ko Ko
AU - Sato, Noriko
AU - Mieno, Makiko Naka
AU - Arai, Tomio
AU - Muramatsu, Masaaki
N1 - Funding Information:
This study was supported by GMEXT/JSPS KAKENHI [grant number 17K09081 ]; Nanken-Kyoten (M.M.) and Smoking Research Foundation (T.A.). Appendix A
Funding Information:
This study was supported by GMEXT/JSPS KAKENHI [grant number 17K09081]; Nanken-Kyoten (M.M.) and Smoking Research Foundation (T.A.).
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - The HOTAIR gene encodes a long noncoding RNA (lncRNA), which functions in development and tumorigenesis. A single nucleotide polymorphism (SNP) rs920778 in the HOTAIR gene, has been recurrently studied for susceptibility to many cancers including oesophageal cancer, gastric cancer, lung cancer, and hepatocellular carcinoma. Most of these studies were conducted in Chinese populations, and a few in Turkish, Iranian, and Portuguese populations. They mostly give rise to controversial results. It still remains largely unknown whether the cancer risk is conferred in a Japanese population. Here, we established an association study on the representative SNP rs920778, to examine its contribution to the presence of cancer in consecutive autopsy cases in the JG-SNP database. A total of 1373 subjects (mean age 80) including 827 cancer positive and 546 cancer negative subjects were analyzed. As a result, the occurrence of overall cancer was not associated with the rs920778 polymorphism (p > 0.05). For each cancer type, we did not find association except for lung cancer (p = 0.04) which was more likely a by-chance association after multiple testing. Our findings imply that rs920778 polymorphism does not affect total cancer presence and the effect on specific cancer types is also weak in the Japanese population.
AB - The HOTAIR gene encodes a long noncoding RNA (lncRNA), which functions in development and tumorigenesis. A single nucleotide polymorphism (SNP) rs920778 in the HOTAIR gene, has been recurrently studied for susceptibility to many cancers including oesophageal cancer, gastric cancer, lung cancer, and hepatocellular carcinoma. Most of these studies were conducted in Chinese populations, and a few in Turkish, Iranian, and Portuguese populations. They mostly give rise to controversial results. It still remains largely unknown whether the cancer risk is conferred in a Japanese population. Here, we established an association study on the representative SNP rs920778, to examine its contribution to the presence of cancer in consecutive autopsy cases in the JG-SNP database. A total of 1373 subjects (mean age 80) including 827 cancer positive and 546 cancer negative subjects were analyzed. As a result, the occurrence of overall cancer was not associated with the rs920778 polymorphism (p > 0.05). For each cancer type, we did not find association except for lung cancer (p = 0.04) which was more likely a by-chance association after multiple testing. Our findings imply that rs920778 polymorphism does not affect total cancer presence and the effect on specific cancer types is also weak in the Japanese population.
KW - Autopsy study
KW - Case-control study
KW - Genetic polymorphisms
KW - HOX transcript antisense RNA
KW - Malignancy
KW - Single nucleotide polymorphism
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U2 - 10.1016/j.gene.2019.144263
DO - 10.1016/j.gene.2019.144263
M3 - Article
C2 - 31759985
AN - SCOPUS:85077361156
SN - 0378-1119
VL - 729
JO - Gene
JF - Gene
M1 - 144263
ER -
