TY - JOUR
T1 - Associations of erythrocyte fatty acid compositions with FADS1 gene polymorphism in Japanese mothers and infants
AU - Nita, Reiko
AU - Kawabata, Terue
AU - Kagawa, Yasuo
AU - Nakayama, Kazuhiro
AU - Yanagisawa, Yoshiko
AU - Iwamoto, Sadahiko
AU - Kimura, Fumiko
AU - Miyazawa, Teruo
AU - Tatsuta, Nozomi
AU - Arima, Takahiro
AU - Yaegashi, Nobuo
AU - Nakai, Kunihiko
N1 - Funding Information:
The authors would like to thank all participants in the study, Research Coordinators and members of the JECS Miyagi Regional Center, and personnel at the antenatal hospitals and clinics that collaborated in this study. The Japan Environment and Children's Study (JECS) was funded by the Ministry of the Environment, Japan. This adjunct study was conducted in Miyagi Regional Center as a part of JECS. The findings and conclusions of this article are solely the responsibility of the authors and do not represent the official views of the Japanese government. This work was supported by the Environment Research and Technology Development Fund from the Ministry of the Environment , Japan (C-1153 ( 2011-2013 ) and 5-1451 ( 2014-2016 )) and by JSPS KAKENHI Grant Number 23617025.
Funding Information:
The authors would like to thank all participants in the study, Research Coordinators and members of the JECS Miyagi Regional Center, and personnel at the antenatal hospitals and clinics that collaborated in this study. The Japan Environment and Children's Study (JECS) was funded by the Ministry of the Environment, Japan. This adjunct study was conducted in Miyagi Regional Center as a part of JECS. The findings and conclusions of this article are solely the responsibility of the authors and do not represent the official views of the Japanese government. This work was supported by the Environment Research and Technology Development Fund from the Ministry of the Environment, Japan (C-1153 (2011-2013) and 5-1451 (2014-2016)) and by JSPS KAKENHI Grant Number 23617025.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/1
Y1 - 2020/1
N2 - Long-chain polyunsaturated fatty acids (LC-PUFAs) are involved in the fetal growth in utero, and are essential for the development of visual and cognitive functions during infancy. The purpose of this study was to examine the associations of erythrocyte fatty acid compositions with FADS1 gene polymorphism in Japanese mothers and infants. The subjects were 383 mothers who participated in an adjunct birth cohort study of the Japan Environment and Children's Study (JECS). In maternal FADS1 SNP genotypes, the precursor fatty acids composition of the Δ5 desaturase in the maternal blood showed significant differences in levels among the groups, and showed increasing values in the order of TT < TC < CC genotype groups. On the other hand, many product fatty acids levels were significantly reduced in the order of TT > TC > CC genotype groups, and DHA levels were significantly lower in the CC genotype group relative to the other groups. Likewise, the relationship between fetal genotype group and fatty acid composition in cord blood was very similar to the maternal relationship. These results indicate the maternal and fetal blood fatty acid compositions are strongly influenced by the FADS1 genotypes. With respect to the cord blood DHA composition, the levels in the fetal CC genotype group showed a trend toward lower values in the maternal CC genotype group pair (p = 0.066) compared to the maternal TC genotype group pair. However, in the fetal TT and TC genotype groups (p = 0.131, p = 0.729, respectively), the maternal genotype did not have a significant effect. The DHA composition was more influenced by the maternal genotype in the fetal CC genotype group than in the fetal TT and TC genotype groups. It was shown that DHA transport via the placenta from the mother might be promoted in the fetal CC genotype compared to the other fetal genotype groups. In conclusion, differences in the FADS1 SNP genotypes of pregnant women and their children may greatly affect the supply of LC-PUFAs. Further studies on the involvement of the FADS1 polymorphisms and the fetal LC-PUFA levels in the fetal growth and development are warranted.
AB - Long-chain polyunsaturated fatty acids (LC-PUFAs) are involved in the fetal growth in utero, and are essential for the development of visual and cognitive functions during infancy. The purpose of this study was to examine the associations of erythrocyte fatty acid compositions with FADS1 gene polymorphism in Japanese mothers and infants. The subjects were 383 mothers who participated in an adjunct birth cohort study of the Japan Environment and Children's Study (JECS). In maternal FADS1 SNP genotypes, the precursor fatty acids composition of the Δ5 desaturase in the maternal blood showed significant differences in levels among the groups, and showed increasing values in the order of TT < TC < CC genotype groups. On the other hand, many product fatty acids levels were significantly reduced in the order of TT > TC > CC genotype groups, and DHA levels were significantly lower in the CC genotype group relative to the other groups. Likewise, the relationship between fetal genotype group and fatty acid composition in cord blood was very similar to the maternal relationship. These results indicate the maternal and fetal blood fatty acid compositions are strongly influenced by the FADS1 genotypes. With respect to the cord blood DHA composition, the levels in the fetal CC genotype group showed a trend toward lower values in the maternal CC genotype group pair (p = 0.066) compared to the maternal TC genotype group pair. However, in the fetal TT and TC genotype groups (p = 0.131, p = 0.729, respectively), the maternal genotype did not have a significant effect. The DHA composition was more influenced by the maternal genotype in the fetal CC genotype group than in the fetal TT and TC genotype groups. It was shown that DHA transport via the placenta from the mother might be promoted in the fetal CC genotype compared to the other fetal genotype groups. In conclusion, differences in the FADS1 SNP genotypes of pregnant women and their children may greatly affect the supply of LC-PUFAs. Further studies on the involvement of the FADS1 polymorphisms and the fetal LC-PUFA levels in the fetal growth and development are warranted.
KW - Cord blood
KW - Erythrocyte fatty acid compositions
KW - FADS1 SNP
KW - LC-PUFAs
KW - Maternal and infant
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U2 - 10.1016/j.plefa.2019.102031
DO - 10.1016/j.plefa.2019.102031
M3 - Article
C2 - 31923811
AN - SCOPUS:85077357826
SN - 0952-3278
VL - 152
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
M1 - 102031
ER -