Asymmetric Aldol Reaction of Dichloroacetaldehyde Catalyzed by Diarylprolinol

Yujiro Hayashi, Daichi Nakamura, Yusuke Yasui, Kotaro Iwasaki, Hiroaki Chiba

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The asymmetric cross-aldol reaction of dichloroacetaldehyde with aldehyde pronucleophiles proceeds in the presence of a trifluoromethyl-substituted diarylprolinol to afford γ,γ-dichloro-β-hydroxy aldehydes in good yield with excellent enantioselectivity. The obtained products are useful synthetic intermediates; they were successfully converted to form chiral alkynes and dichloroalkenes. (Figure presented.) .

Original languageEnglish
Pages (from-to)2345-2351
Number of pages7
JournalAdvanced Synthesis and Catalysis
Issue number14
Publication statusPublished - 2016 Jul 14


  • aldol reaction
  • asymmetric synthesis
  • dichloroacetaldehyde
  • organocatalysts


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