Asymmetric aldol reaction of formaldehyde catalyzed by diarylprolinol

Yusuke Yasui, Meryem Benohoud, Itaru Sato, Yujiro Hayashi

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


The asymmetric cross-aldol reaction of formaldehyde with aldehyde pronucleophiles, catalyzed by trifluoromethyl-substituted diarylprolinol 1, was accomplished to directly afford β-hydroxymethyl-substituted aldehydes in good yield with excellent enantioselectivity.

Original languageEnglish
Pages (from-to)556-558
Number of pages3
JournalChemistry Letters
Issue number4
Publication statusPublished - 2014


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