Asymmetric aldol reaction of formaldehyde catalyzed by diarylprolinol

Yusuke Yasui; Meryem Benohoud; Itaru Sato; Yujiro Hayashi

doi:10.1246/cl.131199

Asymmetric aldol reaction of formaldehyde catalyzed by diarylprolinol

Yusuke Yasui, Meryem Benohoud, Itaru Sato, Yujiro Hayashi

SCI - Chemistry

Tohoku University

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The asymmetric cross-aldol reaction of formaldehyde with aldehyde pronucleophiles, catalyzed by trifluoromethyl-substituted diarylprolinol 1, was accomplished to directly afford β-hydroxymethyl-substituted aldehydes in good yield with excellent enantioselectivity.

Original language	English
Pages (from-to)	556-558
Number of pages	3
Journal	Chemistry Letters
Volume	43
Issue number	4
DOIs	https://doi.org/10.1246/cl.131199
Publication status	Published - 2014

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10.1246/cl.131199

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title = "Asymmetric aldol reaction of formaldehyde catalyzed by diarylprolinol",

abstract = "The asymmetric cross-aldol reaction of formaldehyde with aldehyde pronucleophiles, catalyzed by trifluoromethyl-substituted diarylprolinol 1, was accomplished to directly afford β-hydroxymethyl-substituted aldehydes in good yield with excellent enantioselectivity.",

author = "Yusuke Yasui and Meryem Benohoud and Itaru Sato and Yujiro Hayashi",

year = "2014",

doi = "10.1246/cl.131199",

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journal = "Chemistry Letters",

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T1 - Asymmetric aldol reaction of formaldehyde catalyzed by diarylprolinol

AU - Yasui, Yusuke

AU - Benohoud, Meryem

AU - Sato, Itaru

AU - Hayashi, Yujiro

PY - 2014

Y1 - 2014

N2 - The asymmetric cross-aldol reaction of formaldehyde with aldehyde pronucleophiles, catalyzed by trifluoromethyl-substituted diarylprolinol 1, was accomplished to directly afford β-hydroxymethyl-substituted aldehydes in good yield with excellent enantioselectivity.

AB - The asymmetric cross-aldol reaction of formaldehyde with aldehyde pronucleophiles, catalyzed by trifluoromethyl-substituted diarylprolinol 1, was accomplished to directly afford β-hydroxymethyl-substituted aldehydes in good yield with excellent enantioselectivity.

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DO - 10.1246/cl.131199

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VL - 43

SP - 556

EP - 558

JO - Chemistry Letters

JF - Chemistry Letters

IS - 4

ER -

Asymmetric aldol reaction of formaldehyde catalyzed by diarylprolinol

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