Asymmetric aldol reaction of glyoxal catalyzed by diarylprolinol

Yujiro Hayashi; Masahiro Kojima

doi:10.1002/cctc.201300247

Asymmetric aldol reaction of glyoxal catalyzed by diarylprolinol

Yujiro Hayashi, Masahiro Kojima

SCI - Chemistry

Tokyo University of Science

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

All selection should be this- eeasy: The direct asymmetric aldol reaction of commercial aqueous glyoxal is catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a β-formyl-β-hydroxy-α-substituted aldehyde in good yield with excellent anti selectivity and excellent enantioselectivity.

Original language	English
Pages (from-to)	2883-2885
Number of pages	3
Journal	ChemCatChem
Volume	5
Issue number	10
DOIs	https://doi.org/10.1002/cctc.201300247
Publication status	Published - 2013 Oct

Keywords

Aldol reaction
Asymmetric synthesis
Enantioselectivity
Glyoxal
Organocatalysis

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10.1002/cctc.201300247

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title = "Asymmetric aldol reaction of glyoxal catalyzed by diarylprolinol",

abstract = "All selection should be this- eeasy: The direct asymmetric aldol reaction of commercial aqueous glyoxal is catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a β-formyl-β-hydroxy-α-substituted aldehyde in good yield with excellent anti selectivity and excellent enantioselectivity.",

keywords = "Aldol reaction, Asymmetric synthesis, Enantioselectivity, Glyoxal, Organocatalysis",

author = "Yujiro Hayashi and Masahiro Kojima",

year = "2013",

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AU - Kojima, Masahiro

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AB - All selection should be this- eeasy: The direct asymmetric aldol reaction of commercial aqueous glyoxal is catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a β-formyl-β-hydroxy-α-substituted aldehyde in good yield with excellent anti selectivity and excellent enantioselectivity.

KW - Aldol reaction

KW - Asymmetric synthesis

KW - Enantioselectivity

KW - Glyoxal

KW - Organocatalysis

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Asymmetric aldol reaction of glyoxal catalyzed by diarylprolinol

Abstract

Keywords

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