Asymmetric synthesis of 3,4-dihydrocoumarins by rhodium-catalyzed reaction of 3-(2-hydroxyphenyl)cyclobutanones

Takanori Matsuda, Masanori Shigeno, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

213 Citations (Scopus)

Abstract

3,4-Dihydrocoumarin derivatives were synthesized in a highly enantioselective manner from 3-(2-hydroxyphenyl)cyclobutanones through enantioselective carbon-carbon bond cleavage. A cascade reaction with electron-deficient alkenes introduced a carbon-carbon bond at the 5-position of the dihydrocoumarins.

Original languageEnglish
Pages (from-to)12086-12087
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number40
DOIs
Publication statusPublished - 2007 Oct 10

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