Autoantibodies in neuromyelitis optica spectrum disorders

Ichiro Nakashima, Tetsuya Akaishi

Research output: Contribution to journalArticlepeer-review


Neuromyelitis optica was previously considered a subtype of multiple sclerosis until a specific serum antibody, NMO-IgG, was discovered in 2004. In 2012, anti-MOG antibody was found specifically in the serum of patients whose presentation was similar to those with neuromyelitis optica. These autoantibodies are pathogenic and are important disease markers when reaching a diagnosis.

Original languageEnglish
Pages (from-to)297-304
Number of pages8
JournalBrain and Nerve
Issue number4
Publication statusPublished - 2018 Apr


  • Aquaporin-4
  • Auto-antibody
  • Multiple sclerosis
  • Myelin oligodendrocyte glycoprotein
  • Neuromyelitis optica


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