Autoimmune neutropenia in pregnant women causing neonatal neutropenia

Junichi Kameoka, Tadao Funato, Toshihiko Miura, Hideo Harigae, Junko Saito, Hisayuki Yokoyama, Shinichiro Takahashi, Minami Yamada, Osamu Sasaki, Masue Imaizumi, Noboru Takata, Kuniaki Meguro, Takeshi Sasaki

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Autoimmune neutropenia (AIN) can occur during pregnancy. However, neonatal neutropenia occurring in an infant born to a mother with AIN has only rarely been documented. Recently, we have experienced two cases of AIN during pregnancy, both of which caused severe yet transient neonatal neutropenia (< 0.3 × 109/l), probably as a result of transplacental maternal anti-neutrophil autoantibodies. The anti-neutrophil antibodies seemed to be against antigens other than NA1/NA2 because the autoantibodies did not bind to neutrophils of specific NA types selectively in the granulocyte indirect immunofluorescence test. Although AIN is a relatively uncommon disease, neonatal neutropenia caused by maternal AIN may not be quite as rare.

Original languageEnglish
Pages (from-to)198-200
Number of pages3
JournalBritish Journal of Haematology
Issue number1
Publication statusPublished - 2001


  • Autoimmune neutropenia
  • Granulocyte indirect immunofluorescence test
  • NA antigens
  • Neonatal neutropenia
  • Pregnancy


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