Autoxidation of ethyl eicosapentaenoate and docosahexaenoate

Soon Yeong Cho, Kazuo Miyashita, Teruo Miyazawa, Kenshiro Fujimoto, Takashi Kaneda

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135 Citations (Scopus)


The extent of oxidation of ethyl esters of eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) was compared quantitatively with that of ethyl linoleate (Lo) and ethyl linolenate (Ln) by oxygen uptake and formation of conjugated diene, hydroperoxide and secondary oxidation products. EPA and DHA esters were oxidized rapidly even at 5 C in the dark after an induction period of 3–4 days, while the induction periods of Ln and Lo esters were 20 days and more than 60 days, respectively. Oxygen uptake of EPA and DHA esters after the induction period was 5.2 and 8.5 times faster than that of ethyl Ln, respectively. Hydroperoxides of EPA and DHA esters are much less stable than those of ethyl Lo. The peroxide value is not necessarily a good indication of oxidation in these polyenoic acids because a considerable amount of secondary products is formed at the early stage of oxidation. Polymers were found to be major secondary products in these polyenoic esters.

Original languageEnglish
Pages (from-to)876-879
Number of pages4
JournalJournal of the American Oil Chemists Society
Issue number6
Publication statusPublished - 1987 Jun

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry


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